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Research

Current options in aerosolised drug therapy for children receiving respiratory support

In this review, we explore current knowledge and provide guidance as to when and how the inhaled route may be of value when treating patients whose tracheas are intubated

Research

ACE inhibitors and statins in adolescents with type 1 diabetes

We hypothesized that adolescents with high levels of albumin excretion might benefit from ACE inhibitors and statins, drugs that have not been fully evaluated

Research

Surgical pleth index: Prediction of postoperative pain in children?

It was the aim of this study to define a clinically appropriate SPI target to predict moderate-severe postoperative pain in children.

Research

Randomized controlled trial of text message reminders for increasing influenza vaccination

We conducted a randomized controlled trial of short message service (SMS) reminders for influenza vaccination.

Research

Oxidative stress in early cystic fibrosis lung disease is exacerbated by airway glutathione deficiency

are oxidative stress or glutathione status associated with brochiectasis and whether glutathione deficiency is inherently linked to CF or from oxidative stress

Research

Airway IRF7hi versus IRF7lo molecular response patterns determine clinical phenotypes in children with acute wheezing

We employed a systems biology approach to delineate upper airway gene network patterns underlying asthma exacerbation phenotypes in children.

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Epigenetics in infectious diseases

Viruses, bacteria, and parasites have developed strategies to invade and establish long-term infections in their hosts.

Research

Insights into the possible role of IFNG and IFNGR1 in Kala-azar and Post Kala-azar Dermal Leishmaniasis in Sudanese patients

Uniformly low expression of IFN and IFNGR1 in PKDL skin biopsies could explain parasite persistence

Research

The stark reality of rheumatic heart disease

This editorial refers to ‘Characteristics, complications, and gaps in evidence-based interventions in rheumatic heart disease: the Global Rheumatic Heart...