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A common genetic variant of a mitochondrial RNA processing enzyme predisposes to insulin resistanceMitochondrial energy metabolism plays an important role in the pathophysiology of insulin resistance. Recently, a missense N437S variant was identified in the MRPP3 gene, which encodes a mitochondrial RNA processing enzyme within the RNase P complex, with predicted impact on metabolism. We used CRISPR-Cas9 genome editing to introduce this variant into the mouse Mrpp3 gene and show that the variant causes insulin resistance on a high-fat diet.
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Illuminate Sundowner 2024Illuminate Awards are a philanthropic initiative - shining a light on child health research to help all kids lead happy, healthy lives.
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Meet the Finalists: Illuminate PitchFest 2024Illuminate PitchFest is back! We are excited to introduce you to 10 trailblazing researchers who will be taking to the stage this February to pitch their bold and bright ideas.
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Introducing Illuminate PitchFestAt The Kids our greatest asset is our people. We are strongly invested in the future of child medical research welcoming, nurturing, and encouraging the best and most innovative Australian and international researchers.
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Meet the Researcher: Dr Samantha CarlsonDr Samantha Carlson is an early career mixed-methods social scientist, leading research that seeks to understand how to improve access to and understanding about vaccination.