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Research
Novel GABAAR antagonists target networked gene hubs at the leading-edge in high-grade gliomasIon channel activity underlying biological processes that drive high-grade gliomas (HGG) is largely unknown. We aimed to determine the networking of ion channel genes and validate their expression within HGG patient tumors, to identify ion channel-targeting drugs that would inhibit tumor-promoting processes.
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Cutting edge spatial maps reveal Western Pacific hotspots for parasitic wormsA global research team led by geospatial modelling experts from The Kids Research Institute Australia and Curtin University has provided the first detailed maps identifying hotspots across the Western Pacific Region where debilitating parasitic worms are rife.
Research
Real-world benefits and tolerability of trofinetide for the treatment of Rett syndrome: The LOTUS studyAim: To describe the real-world effects of trofinetide in individuals with Rett syndrome (RTT) using the 18-month follow-up analysis of the LOTUS study.
Research
Finding the optimal regimen for Mycobacteroides abscessus treatment (FORMaT) in people with Mycobacteroides abscessus pulmonary diseaseMycobacteroides abscessus (MABS) is within the non-tuberculous mycobacteria family. It inhabits soil and water, exhibits multi-antibiotic resistance and causes opportunistic lung infections, which may progress to symptomatic MABS-pulmonary disease (MABS-PD) associated with substantial morbidity, increased healthcare utilisation, impaired quality of life and increased mortality.
Research
Intrauterine growth restriction promotes hypothalamic circadian dysregulation in adult mouse offspringAdverse prenatal conditions can induce intrauterine growth restriction and increase the risk of adulthood metabolic disease. Mechanisms underlying developmentally programmed metabolic disease remain unclear but may involve disrupted postnatal circadian rhythms and kisspeptin signalling.
Research
“Wait with me until it's over”: A reflexive thematic analysis of adolescents’ coping with dissociationDissociation is often distressing, yet how affected adolescents manage dissociation in their daily lives is not well understood. This study aimed to describe the strategies adolescents use to manage dissociative symptoms from the perspective of adolescents themselves, their parents, and their clinicians.
Research
Dog Ownership, Physical Activity, and Mental Health in Mid-to-Older Aged Adults: Findings From the HABITAT Cohort StudyDog ownership is a potential strategy for maintaining physical activity levels and supporting healthy aging. This study examined longitudinal effects of dog ownership and dog walking on physical activity and mental health in mid-to-older aged adults.
At just six months old, Tahlea Dalgety was flown from Geraldton to Perth with a slim chance of survival after contracting meningococcal disease.
News & Events
Major NHMRC grant prioritises strong skin for Aboriginal childrenEfforts to improve health outcomes for Aboriginal children have been accelerated thanks to almost $1 million in National Health and Medical Research Council (NHMRC) funds awarded to skin health researchers at The Kids Research Institute Australia.
Research
Drug-resistant gram-negative bacterial infections in children in the Oceania region: review of the epidemiology, antimicrobial availability, treatment, clinical trial and pharmacokineticGram-negative bacterial infections remain a major cause of morbidity and mortality in children and neonates globally, compounded by the rise of antimicrobial resistance. Barriers to paediatric antibiotic licencing lead to reduced availability of potentially effective agents for treatment. For children and neonates in the Oceania region, specific challenges remain including a paucity of surveillance data on local rates of antimicrobial resistance, and lack of availability of newer, more costly agents.