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Interpretation of lung function in infants and young children with cystic fibrosis

This paper is a review of lung function tests best suited to use for early detection of lung disease in Cystic Fibrosis.

Using lung function measurements to greater advantage in patients with lung disease: Which test and when?

This paper is an introduction to a series of articles about improved measurement of lung function in patients with chronic lung disease.

Vitamin D deficiency at 16 to 20 weeks' gestation is associated with impaired lung function and asthma at 6 years of age

This paper examines whether a Vitamin D deficiency during pregnancy affects the child's lung function predisposition towards lung disease such as asthma.

Home oxygen therapy for infants and young children with acute bronchiolitis and other lower respiratory tract infections: The HiTHOx program

Recent studies have demonstrated that some children with acute bronchiolitis can be successfully managed using home oxygen therapy.

Effects of adopting the new global lung function initiative 2012 reference equations on the interpretation of spirometry

The aim of this study was to document the likely interpretative effects of changing from commonly used current spirometry reference equations to the GLI2012...

Novel end points for clinical trials in young children with cystic fibrosis

Cystic fibrosis (CF) lung disease commences early in the disease progression and is the most common cause of mortality.

The Global Lung Initiative 2012 reference values reflect contemporary Australasian spirometry

We aimed to ascertain the fit of the European Respiratory Society Global Lung Initiative 2012 reference ranges to contemporary Australasian spirometric data.

Age- and height-based prediction bias in spirometry reference equations

Prediction bias in spirometry reference equations can arise from combining equations for different age groups,...

Oscillometry and spirometry are not interchangeable when assessing the bronchodilator response in children and young adults born preterm

The European Respiratory Society Oscillometry Taskforce identified that clinical correlates of bronchodilator responses are needed to advance oscillometry in clinical practice. The understanding of bronchodilator-induced oscillometry changes in preterm lung disease is poor. Here we describe a comparison of bronchodilator assessments performed using oscillometry and spirometry in a population born very preterm and explore the relationship between bronchodilator-induced changes in respiratory function and clinical outcomes.

Risk factors for poorer respiratory outcomes in adolescents and young adults born preterm

The respiratory outcomes for adult survivors of preterm birth in the postsurfactant era are wide-ranging with prognostic factors, especially those encountered after the neonatal period, poorly understood.