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Signal-correction errors in the EasyOne Pro LAB multiple-breath washout device significantly impact outcomes in children and adults

Multiple-breath washout (MBW) is an established technique to assess functional residual capacity (FRC) and ventilation inhomogeneity in the lung. Indirect calculation of nitrogen concentration requires accurate measurement of gas concentrations.

Citation:
Oestreich MA, Wyler F, Buess C, Etter B, Ramsey KA, Latzin P. Signal-correction errors in the EasyOne Pro LAB multiple-breath washout device significantly impact outcomes in children and adults. J Appl Physiol (1985). 2024;136(3):460-71.

Keywords:
Cystic fibrosis; lung clearance index; lung disease; pulmonary function testing; ventilation inhomogeneity

Abstract:
Multiple-breath washout (MBW) is an established technique to assess functional residual capacity (FRC) and ventilation inhomogeneity in the lung. Indirect calculation of nitrogen concentration requires accurate measurement of gas concentrations.