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Research

Infant respiratory infections and later respiratory hospitalisation in childhood

The aim of this study was to use total-population based data on an otherwise healthy population of children to assess the relationship between early...

Research

Effectiveness of Palivizumab against Respiratory Syncytial Virus: Cohort and Case Series Analysis

Palivizumab appeared effective for reducing virologically confirmed respiratory syncytial virus in this high-risk cohort

Research

Clinical description and outcomes of Australian children with invasive group a streptococcal disease

Invasive group A streptococcal infection in Australian children is frequently severe and has a high long-term morbidity burden

Research

Spatial clustering of notified tuberculosis in Ethiopia: A nationwide study

Substantial spatial clustering of notified tuberculosis was detected at region, zone and district level in Ethiopia

Research

Do rapid diagnostic methods improve antibiotic prescribing in paediatric bacteraemia?

Rapid blood culture pathogen identification facilitated by matrix-assisted laser desorption ionisation time-of-flight and GeneXpert has the potential to improve antibiotic prescribing. This study investigates the impact of these rapid diagnostics on the timeliness of effective and optimal antibiotic prescribing in paediatric patients with bacteraemia.

Research

Record linkage study of the pathogen-specific burden of respiratory viruses in children

Reliance on hospital discharge diagnosis codes alone will likely underestimate the burden of respiratory viruses

Research

Viral etiology and the impact of codetection in young children presenting with influenza-like illness

Children with acute respiratory tract infection (ARTI) frequently exhibit virus-virus codetection, yet the clinical significance of ARTI remains contentious.

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Characterizing the risk of respiratory syncytial virus in infants with older siblings: a population-based birth cohort study

Our results lend support to a vaccination strategy which includes family members in order to provide maximum protection for newborn babies.

Research

The Changing Detection Rate of Respiratory Syncytial Virus in Adults in Western Australia between 2017 and 2023

The incidence of respiratory syncytial virus (RSV) in adults is inadequately defined and the impact of SARS-CoV-2-related non-pharmaceutical interventions (NPIs) is underexplored. Using laboratory data, we described the detection rate of RSV in adults ≥16 years in Western Australia (WA) between 2017 and 2023.

Research

Head-to-Head Comparison Between Respiratory Syncytial Virus and Human Metapneumovirus Bronchiolitis in the Setting of Increased Viral Testing

We compared the epidemiology, severity and management of hospitalized respiratory syncytial virus (n = 305) and human metapneumovirus (n = 39) bronchiolitis in a setting with high respiratory virus testing (95% of admissions tested). Respiratory syncytial virus-positive infants were younger and tended to require more hydration support and longer hospital stays compared to human metapneumovirus-positive infants. Respiratory support requirements were similar between groups despite significant age differences.