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Pertussis burden and acellular pertussis vaccine effectiveness in high risk children

Pertussis hospitalisation is more common among infants born prematurely, who have significant comorbidities, or are Indigenous, but acellular pertussis (aP) vaccine effectiveness (VE) estimates in these sub-groups are lacking. We measured aP VE by Indigenous status, and policy-relevant categories of prematurity and comorbidity, in a population-based Australian cohort.

Citation:
Sheridan S, McIntyre P, Liu B, Fathima P, Snelling T, Blyth CC, de Klerk N, Moore H, Gidding H. Pertussis burden and acellular pertussis vaccine effectiveness in high risk children. Vaccine. 2022:40(9); 1376-1382.

Keywords:
Comorbid conditions; Data linkage; Indigenous; Pertussis; Prematurity; Vaccine effectiveness

Abstract:
Pertussis hospitalisation is more common among infants born prematurely, who have significant comorbidities, or are Indigenous, but acellular pertussis (aP) vaccine effectiveness (VE) estimates in these sub-groups are lacking. We measured aP VE by Indigenous status, and policy-relevant categories of prematurity and comorbidity, in a population-based Australian cohort.