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Head, Pregnancy and Early Life Immunology

Multiple sclerosis (MS) demonstrates a latitude gradient in prevalence and severity, implicating ultraviolet B (UVB) exposure and photoimmune mechanisms in disease risk and progression. While narrowband (NB)-UVB phototherapy has long stabilized inflammation in dermatology, its systemic immunomodulatory effects in MS remain incompletely defined.

Atopic asthma, which is at its highest prevalence during childhood/young adulthood, represents the main focus of this review.

Airways hyperresponsiveness (AHR) is one of the major clinical features of allergic airways disease including allergic asthma

We have recently published a paper identifying precursor populations in peripheral lung (2017), and have also discovered that these populations can be found in multiple tissues.

This study will identify how the immune system contributes to neurodevelopmental outcomes and will investigate the use of an agent from traditional medicines.

This study will investigate the why disease is worse in infants and how early life viral infection impacts the developing immune system.

This is a strategic “pilot” project in which we are seeking basic information on the immune cell content of gestational tissues.

This project investigates how different populations of cells within the respiratory tract immune system are altered during a viral infection.

The high burden of peanut allergy underscores the need for treatment options that improve patient health-related quality of life (HRQL). However, the modifying effect of sex assigned at birth on treatment-related outcomes remains poorly understood. We sought to investigate whether sex modifies treatment effect on the change in overall and subdomain HRQL during the PPOIT-003 trial.