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Research
A multi-country investigation of influenza vaccine coverage in pregnant individuals, 2010–2016Many countries recommend influenza vaccination during pregnancy. Despite this recommendation, influenza vaccine among pregnant individuals remains under-utilized and uptake varies by country. Factors associated with influenza vaccine uptake during pregnancy may also vary across countries.
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Climate change, activism, and supporting the mental health of children and young people: Perspectives from Western AustraliaThe climate crisis has detrimental impacts on the mental health and wellbeing of children and young people. Psychological effects include feelings of fear, overwhelm, worry, distress, hopelessness and anger; PTSD; depression; anxiety; phobias; panic disorder; sleep disturbances; attachment disorders; learning difficulties; substance abuse; shock and trauma symptoms; adjustment problems; behavioural problems; and, suicidal thinking.
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Target identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide libraryGenetic screening technologies to identify and validate macromolecular interactions (MMIs) essential for complex pathways remain an important unmet need for systems biology and therapeutics development. Here, we use a library of peptides from diverse prokaryal genomes to screen MMIs promoting the nuclear relocalization of Forkhead Box O3 (FOXO3a), a tumor suppressor more frequently inactivated by post-translational modification than mutation.
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Novel oncogenic PDGFRA mutations in pediatric high-grade gliomasThe outcome for children with high-grade gliomas (HGG) remains dismal, with a 2-year survival rate of only 10% to 30%.
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Excessive daytime sleepiness increases the risk of motor vehicle crash in obstructive sleep apneaOur objectives were to describe the incidence rate of motor vehicle crashes (MVCs) in patients with obstructive sleep apnea (OSA) and to investigate MVC risk...
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The Differential Influence of Contextual Risks on Psychosocial Functioning and Participation of Australian Aboriginal YouthMethodological issues and implications for interventions to support young Aboriginal people's adaptation are discussed.
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Chest computed tomography: a validated surrogate endpoint of cystic fibrosis lung disease?Clinical trials for the treatment of cystic fibrosis (CF) lung disease are important to test and optimise new therapeutic interventions.
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Common variation contributes to the genetic architecture of social communication traitsSocial communication difficulties represent an autistic trait that is highly heritable and persistent during the course of development.
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A "bottom-up" approach to aetiological research in autism spectrum disordersAutism spectrum disorders (ASD) are currently diagnosed in the presence of impairments in social interaction and communication, and a restricted range of...
Research
DSM-IV-TR and DSM-5 eating disorders in adolescents: Prevalence, stability, and psychosocial correlates in a population-based sampleEating disorder prevalence rates were significantly greater when using DSM-5 than DSM- IV-TR criteria, at all time points for females and at age 17 only...