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Research
Erdosteine in children and adults with bronchiectasis (BETTER trial): study protocol for a multicentre, double-blind, randomised controlled trialBronchiectasis is a worldwide chronic lung disorder where exacerbations are common. It affects people of all ages, but especially Indigenous populations in high-income nations. Despite being a major contributor to chronic lung disease, there are no licensed therapies for bronchiectasis and there remain relatively few randomised controlled trials (RCTs) conducted in children and adults.
Research
Cough in Children and Adults: Diagnosis, Assessment and Management (CICADA). Summary of an updated position statement on chronic cough in AustraliaCough is the most common symptom leading to medical consultation. Chronic cough results in significant health care costs, impairs quality of life, and may indicate the presence of a serious underlying condition. Here, we present a summary of an updated position statement on cough management in the clinical consultation.
Research
Surfactant protein disorders in childhood interstitial lung diseaseSurfactant, which was first identified in the 1920s, is pivotal to lower the surface tension in alveoli of the lungs and helps to lower the work of breathing and prevents atelectasis. Surfactant proteins, such as surfactant protein B and surfactant protein C, contribute to function and stability of surfactant film.
Research
Recognition and Management of Protracted Bacterial Bronchitis in Australian Aboriginal Children: A Knowledge Translation ApproachChronic wet cough in children is the hallmark symptom of protracted bacterial bronchitis (PBB) and if left untreated can lead to bronchiectasis, which is prevalent in Indigenous populations. Underrecognition of chronic wet cough by parents and clinicians and underdiagnosis of PBB by clinicians are known.
Research
Data resource profile: The Australian early development index (AEDI)This paper describes the Australian Early Development Index, a developmental census conducted by the Australian Government across the entire population of...
Research
Mapping the landscape of chromatin dynamics during naïve CD4+ T-cell activationT-cell activation induces context-specific gene expression programs that promote energy generation and biosynthesis, progression through the cell cycle and ultimately cell differentiation. The aim of this study was to apply the omni ATAC-seq method to characterize the landscape of chromatin changes induced by T-cell activation in mature naïve CD4+ T-cells.

Exploring the challenges to mental and physical health fathers face during their transition to parenthood.

CliniKids is a not-for-profit centre integrating world-class research with a clinical service for children with developmental delay and/or autism, and their families. It is the first of its kind for autism in Australia.

Find out more about CliniKids' new program which boosts early language skills through book sharing.

News & Events
Trans young people can benefit from puberty suppressionA major review by WA researchers has found medication used to suppress puberty can improve the mental health of young people who are trans or gender diverse.