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Research
The detection of bile acids in the lungs of paediatric cystic fibrosis patients is associated with altered inflammatory patternsOur work has identified a clinically relevant host-derived factor that may participate in shaping early events in the aetiology of CF respiratory disease
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A positive feedback loop between alpha1-adrenoceptors and inflammatory cytokines in keratinocytesOur results suggest that reciprocal influences between alpha1-adrenoceptors and inflammatory cytokines may play a role in normal inflammatory responses
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New genetic predictors for abacavir tolerance in HLA-B*57:01 positive individualsWe investigated immune and non-immune related genes to determine other factors required for the development of Abacavir hypersensitivity syndrome
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Content validation of the Quality of Life Inventory—DisabilitySatisfactory content validity is reported, where ongoing consumer feedback shaped the dataset from which the final items were selected
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Improvement in Psychosocial Outcomes in Children with Type 1 Diabetes and Their Parents Following Subsidy for Continuous Glucose MonitoringIntroduction of subsidized CGM showed early improvement in psychosocial and glycemic outcomes in patients and their families in Western Australia
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Choosing primary endpoints for clinical trials of health care interventionsThis narrative review describes the evolution, range and relative strengths and weaknesses of endpoints used in late phase trials
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Azithromycin reduces airway inflammation induced by human rhinovirus in lung allograft recipientsOur data illustrate that rhinovirus infection is capable of infecting upper and lower airway epithelial cells, driving cell death and inflammation
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Coffee and tea consumption during pregnancy and risk of childhood acute myeloid leukemia: A Childhood Leukemia International Consortium (CLIC) studyWe investigated the potential association of maternal coffee and tea consumption during pregnancy with childhood acute myeloid leukemia risk
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Sun-immune connectionExposure to ultraviolet radiation damages skin cell DNA but skin cancers develop because ultraviolet radiation also affects the immune system
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Availability and administration of benzathine penicillin G for the prevention of rheumatic fever in Africa: Report of the Working Group on PenicillinBenzathine penicillin G availability should be addressed and African health workers’ knowledge and practices need to be augmented