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The production of functional antipneumococcal antibodies in otitisprone children demonstrates that they respond to the current pneumococcal conjugate vaccine (PCV)and are likely to respond to pneumolysin-based vaccines as effectively as healthy children.
Our findings are in line with a number of epidemiological studies which show a positive association between breastfeeding and OM in early childhood
Conserved vaccine candidate proteins from S.pneumoniae induce serum and salivary antibody responses in Aboriginal and non-Aboriginal children with history of OM
Identified dominant PCR-ribotypes common to geographically disparate Australian paediatric populations
PCV10 did not reduce NTHi density in the nasopharynx or middle ear, and was associated with increased pneumococcal nasopharyngeal density
The relationship between early life episodes of otitis media and later behavioural development with adjustment for confounders.
To assess the effectiveness of antibiotics versus antiseptics for people with chronic suppurative otitis media.
To assess the effects of topical antiseptics for people with chronic suppurative otitis media
To assess the effects of systemic antibiotics for people with chronic suppurative otitis media.
To assess the effects of topical antibiotics for people with chronic suppurative otitis media.