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Impaired calcium influx underlies skewed T helper cell differentiation in children with IgE-mediated food allergiesReasons for Th2 skewing in IgE-mediated food allergies remains unclear. Clinical observations suggest impaired T cell activation may drive Th2 responses evidenced by increased atopic manifestations in liver transplant patients on tacrolimus (a calcineurin inhibitor). We aimed to assess differentiation potential, T cell activation and calcium influx of naïve CD4+ T cells in children with IgE-mediated food allergies.
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Early Peanut Immunotherapy in Children (EPIC) trial: Protocol for a pragmatic randomised controlled trial of peanut oral immunotherapy in children under 5 years of ageFood allergy is a major public health challenge in Australia. Despite widespread uptake of infant feeding and allergy prevention guidelines the incidence of peanut allergy in infants has not fallen, and prevalence of peanut allergy in school-aged children continues to rise. Therefore, effective and accessible treatments for peanut allergy are required.
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Increasing emergency department visits for anaphylaxis in very early childhood: A canary in the coal mineThe incidence of anaphylaxis is increasing globally in tandem with changing environmental and lifestyle factors. There is very limited data on very early childhood presentations. We aim to assess changes in rates, characteristics and management of infant anaphylaxis in a paediatric ED over a 15-year period.
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Food for thought: progress in understanding the causes and mechanisms of food allergyTreatments for food allergy are still lacking, yet progress is being made, and immunotherapy appears more effective than dietary avoidance.
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Disease prevention in the age of convergence - The need for a wider, long ranging and collaborative visionOur global health crisis and the pandemic of noncommunicable diseases (NCDs) is clearly rooted in complex modern societal and environmental changes, many of...
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Propofol use in children with allergies to egg, peanut, soybean or other legumesWe conclude that genuine serious allergic reaction to propofol is rare and is not reliably predicted by a history of food allergy
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Prebiotics: mechanisms and preventive effects in allergyIn this review, we describe both the mechanisms and the therapeutic evidence from preclinical and clinical studies exploring the role of prebiotics in allergy prevention
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Increased Use of Adrenaline in the Management of Childhood Anaphylaxis Over the Last DecadeThere was a significant improvement in the management of anaphylaxis after the introduction of intensified physician training programs
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An Australian Consensus on Infant Feeding Guidelines to Prevent Food Allergy: Outcomes From the Australian Infant Feeding SummitInfant feeding in the first postnatal year of life has an important role in an infant's risk of developing food allergy
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Infant Diet Recommendations Reduce IgE-Mediated Egg, Peanut, and Cow's Milk AllergiesMeta-analyses of randomized controlled trials have found that introducing eggs and peanuts earlier during infancy reduced egg and peanut allergy risk. Hence, infant feeding advice has dramatically changed from previous recommendations of avoidance to current recommendations of inclusion of common food allergens in infant diets.