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Adiposity associated DNA methylation signatures in adolescents are related to leptin and perinatal factorsEpigenetics links perinatal influences with later obesity. We identifed differentially methylated CpG (dmCpG) loci measured at 17 years associated with concurrent adiposity measures and examined whether these were associated with hsCRP, adipokines, and early life environmental factors. Genome-wide DNA methylation from 1192 Raine Study participants at 17 years, identified 29 dmCpGs associated with body mass index, 10 with waist circumference and 9 with subcutaneous fat thickness.
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Using 3D Printing to Visualize 2D Chromatograms and NMR Spectra for the ClassroomThe use of three-dimensional printing in chemistry education has expanded greatly in the past 10 years. The technique has been used to demonstrate a range of concepts including molecular structure, orbitals, and point groups; to produce chemical equipment such as cuvettes and columns; and even to print out mathematical shapes and functions. Here, 3D printing is used to create physical models of two-dimensional NMR spectra and HPLC chromatograms to facilitate student understanding of these challenging concepts.
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Fetal alcohol spectrum disorder and the criminal justice systemFetal Alcohol Spectrum Disorder (FASD) is a condition caused by prenatal exposure to alcohol and characterised by severe neurodevelopmental impairment which have lifelong implications. Impairments in executive function, memory, cognition, language and attention are common, and can lead to early and repeat engagement with the criminal justice system.
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Childhood vaccination and allergy: A systematic review and meta-analysisAs the rise in prevalence of allergic diseases worldwide corresponds in time with increasing infant vaccination, it has been hypothesized that childhood vaccination may increase the risk of allergic disease. We aimed to synthesize the literature on the association between childhood vaccination and allergy.
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Progress towards a coordinated, national paediatric antimicrobial resistance surveillance programmeThese data support that children are not just 'little adults' in the AMR era, and analyses by age group are important to detect differences in antibiotic susceptibility
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Bacterial Reservoirs in the Middle Ear of Otitis-prone Children Are Associated With Repeat Ventilation Tube InsertionPresence of bacterial otopathogen in the middle ear during ventilation tube insertion was a predictor of children at-risk of repeat ventilation tube insertion
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Modelling factors for Aboriginal and Torres Strait Islander child neurodevelopment outcomes: A latent class analysisThis study highlights a range of unique profiles that can be used for improving the early development of young Aboriginal children
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Genetic Manipulation of Group A Streptococcus-Gene Deletion by Allelic ReplacementAn optimized, rapid method for creating markerless isogenic mutations that combines Gibson assembly cloning with a new temperature-sensitive plasmid, pLZts
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Towards the development of an integrative, evidence-based suite of indicators for the prediction of outcome following mild traumatic brain injuryPerformance on neuropsychological measures may be useful for predicting persisting post-concussion symptoms
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Does otitis media in early childhood affect later behavioural development? Results from the Western Australian Pregnancy Cohort (Raine) StudyThe relationship between early life episodes of otitis media and later behavioural development with adjustment for confounders.