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Prevention - what is the most promising approach?This paper is an editorial comment by Professor Patrick Holt on the potential for developing early intervention strategies in children with allergies and asthma
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Neighbourhood Effects Influencing Early Childhood Development: Conceptual Model and Trial Measurement Methodologies from the Kids in Communities StudySocio-environmental factors, including the neighbourhoods in which children live and grow, are key determinants of children's developmental outcomes.
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Multi-modality monitoring of cystic fibrosis lung disease: the role of chest computed tomographyStratification of monitoring protocols based on the risk profile of the patient can help us in the future to better care for people with Cystic Fibrosis.
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A psychometric examination of a modified eight-item version of the children's eating disorder examinationFurthermore, previous studies suggest that scores obtained from a simplified 8-item version of the ChEDE may be more reliable and useful for research...
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What is the optimal level of vitamin D?: Separating the evidence from the rhetoricNew evidence indicates that both high and low 25(OH)D levels may be associated with increased health risks.
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Risk of childhood acute lymphoblastic leukaemia following parental occupational exposure to pesticidesRisk of childhood acute lymphoblastic leukaemia following parental occupational exposure to pesticides.
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Suppression of adrenomedullin contributes to vascular leakage and altered epithelial repair during asthmaThe anti-inflammatory peptide, adrenomedullin (AM), and its cognate receptor are expressed in lung tissue, but its pathophysiological significance in airway...
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The anti-inflammatory actions of IL-4 in human monocytes are not mediated by IL-10, RP105 or the kinase activity of RIPK2The anti-inflammatory actions of IL-4 in activated human monocytes may reflect transcriptional regulation of genes involved in TLR signaling pathways.
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Research performance evaluation: The experience of an independent medical research instituteEvaluation of the social and economic outcomes of health research funding is an area of intense interest and debate...
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Progression of early structural lung disease in young children with cystic fibrosis assessed using CTCross-sectional studies implicate neutrophilic inflammation and pulmonary infection as risk factors for early structural lung disease in infants and young...