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Impaired T cell proliferation by ex vivo BET-inhibition impedes adoptive immunotherapy in a murine melanoma modelWe established a pipeline to assess the effects of epigenetic modifiers on CD8+ T cell proliferation, differentiation, and efficacy in a preclinical melanoma model
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Early life determinants of health: Invest early to break the cycle of long-term disadvantage in neurodevelopmental disordersThis chapter discusses the importance of investment in early life determinants of health to break the cycle of long-term disadvantage. This chapter addresses these issues while focussing on neurodevelopmental disorders and their related mental health concerns as the targets at the centre of a biopsychosocial transformation of the health system.
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Pre-exposure prophylaxis for HIV prevention during pregnancy and lactation: forget not the women and childrenThe framework for appropriately identifying and managing at-risk pregnant and lactating women requiring PrEP is poorly defined
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Effect of combining pre-exercise carbohydrate intake and repeated short sprints on the blood glucose response to exercise in young individuals with Type 1 diabetesWhen carbohydrates are ingested prior to moderate-intensity exercise, adding repeated sprints is not significantly detrimental to glycaemic management
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Indigenous compared with non-Indigenous Australian patients at entry to specialist palliative care: Cross-sectional findings from a multi-jurisdictional datasetIndigenous patients are substantially underrepresented in care by services participating in the nationwide specialist palliative care Collaboration, likely reflecting widespread access barriers.
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Functional connectivity of the vigilant-attention network in children and adolescents with attention-deficit/hyperactivity disorderADHD patients showed substantially diminished intrinsic coupling for 7 connections and increased coupling for 4 connections
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The role of skin testing and extended antibiotic courses in assessment of children with penicillin allergy: An Australian experienceA direct oral provocation challenge with the culprit drug in Australian children can be safely performed, avoiding resource-intensive and painful skin testing
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Is sport an untapped resource for recovery from first episode psychosis? A narrative review and call to actionSport-based interventions could be an opportunity to provide intervention to individuals recovering from their first psychotic episode
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Subjective memory complaints predict baseline but not future cognitive function over three years: Results from the Western Australia Memory StudySubjective memory complaints individuals present distinctive features of memory complaints as compared to non-memory complainers
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Mandatory vaccination and no fault vaccine injury compensation schemes: An identification of country-level policiesCountries that mandate childhood vaccination without providing no fault compensation schemes could be seen as abrogating the social contract