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Sex-Specific Environmental Impacts on Initiation and Progression of Multiple SclerosisThe immunological mechanisms that contribute to multiple sclerosis (MS) differ between males and females. Females are 2-3 times more likely to develop MS compared to males, however the reason for this discrepancy is unknown. Once MS is established, there is a more inflammatory yet milder form of disease in females whereas males generally suffer from more severe disease and faster progression, neural degradation, and disability.
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Systematic Review of the Effects of Ultraviolet Radiation on Markers of Metabolic DysfunctionHere we review the metabolic effects of exposure to ultraviolet radiation, focusing on the effects of phototherapies
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Sun exposure: An environmental preventer of metabolic dysfunction?Emerging preclinical findings suggest that some sun exposure is necessary for optimal metabolic health
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Investigating the relationships between sun exposure and cardiometabolic dysfunctionPeter Shelley Jacoby Gorman BA (Hons) MSc BSc (Hons) PhD Biostatistician Honorary Research Associate Peter.Jacoby@thekids.org.au shelley.gorman@
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Comparing and combining the effects of low dose ultraviolet and physical activityShelley Prue Gorman Hart BSc (Hons) PhD BSc (Hons) MSc PhD Honorary Research Associate Honorary Research Fellow shelley.gorman@thekids.org.au
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Topical 1,25-dihydroxyvitamin D3 subverts the priming ability of draining lymph node dendritic cellsThe active form of vitamin D, 1,25-hydroxyvitamin D(3) [1,25(OH)(2)D(3)] is produced in skin following exposure to sunlight
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Altered immunity and dendritic cell activity in the periphery of mice after long-term engraftment with bone marrow from ultraviolet-irradiated miceTo investigate the immune capabilities of peripheral tissue DCs generated in vivo from the BM of UV-irradiated mice, chimeric mice were established.
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Investigating the roles of regulatory T cells, mast cells and interleukin-9 in the control of skin inflammat roles of regulatory T cells, mast cells and interleukin-9 in the control of skin inflammation by vitamin D. Arch Dermatol Res. 2018;310(3):221-30.We investigated the ability of topical 1,25(OH)2D to suppress contact dermatitis through an IL9 dependent process, examining mast cells and IL9 secreting cells.
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Vitamin D deficiency causes airway hyperresponsiveness and increases airway smooth muscle mass in the lungs of female BALB/c miceWe tested whether there is a causal association between vitamin D deficiency, airway smooth muscle (ASM) mass, and the development of airway hyperresponsiveness
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Identification of genes differentially regulated by vitamin D deficiency that alter lung pathophysiology and inflammation in allergic airways diseaseVitamin D deficiency exacerbates house dust mite-induced inflammation and alterations in lung structure and function