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One explanation for the high burden of allergic and autoimmune diseases in industrialized countries is inappropriate immune development under modern...
The Pregnancy and Early Life Immunology team's overall research vision is targeted towards understanding immunological development during early life.
Information is accumulating which implicates airway inflammation resulting from respiratory viral infections, acting against a background of atopy.
This chapter describes the preparation of respiratory tract tissue from both mice and rats for the isolation of respiratory tract dendritic cells (RTDC).
A hallmark of atopic asthma is development of chronic airways hyper-responsiveness (AHR) that persists in the face of ongoing exposure to perennial...
Our results suggest that inflammatory cytokines released during injury stimulate α1-AR expression in keratinocytes
We describe herein a highly reproducible in vivo passive cutaneous anaphylaxis assay using Sprague Dawley rats for the quantification of ovalbumin-specific IgE
With immune checkpoint therapy (ICT) having reshaped the treatment of many cancers, the next frontier is to identify and develop novel combination therapies to improve efficacy. Previously, we and others identified beneficial immunological effects of the vitamin A derivative tretinoin on anti-tumour immunity.
This study is designed to identify the specific unique immune cell response that occurs in these children with recurrent disease.
Human perinatal life is characterized by a period of extraordinary change during which newborns encounter abundant environmental stimuli and exposure to potential pathogens. To meet such challenges, the neonatal immune system is equipped with unique functional characteristics that adapt to changing conditions as development progresses across the early years of life, but the molecular characteristics of such adaptations remain poorly understood.