Search

We are studying immune cells from identical twins of which one suffers and one does not suffer from allergic disease to identify specific mechanisms that may play important roles in disease development.

Studies in Europe show exposure of pregnant women to high levels of microbial products stimulate immune function maturation in their offspring

This project investigates how cells of the immune system respond to substances to cause allergies to help develop new treatments.

The Pregnancy and Early Life Immunology team's overall research vision is targeted towards understanding immunological development during early life.

The study aims to identify the mechanism for this so that this knowledge can be used to better treat asthma and allergies in both males and females.

This study is designed to identify the specific unique immune cell response that occurs in these children with recurrent disease.

This chapter describes the preparation of respiratory tract tissue from both mice and rats for the isolation of respiratory tract dendritic cells (RTDC).

One explanation for the high burden of allergic and autoimmune diseases in industrialized countries is inappropriate immune development under modern...

We recently reported that offspring of mice treated during pregnancy with the microbial-derived immunomodulator OM-85 manifest striking resistance to allergic airways inflammation, and localized the potential treatment target to fetal conventional dendritic cell (cDC) progenitors. Here, we profile maternal OM-85 treatment-associated transcriptomic signatures in fetal bone marrow, and identify a series of immunometabolic pathways which provide essential metabolites for accelerated myelopoiesis.

In the present study, we sought to evaluate the complement activation product C4d as a marker for lupus nephritis in systemic lupus erythematosus (SLE).