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Research
Novel GABAAR antagonists target networked gene hubs at the leading-edge in high-grade gliomasIon channel activity underlying biological processes that drive high-grade gliomas (HGG) is largely unknown. We aimed to determine the networking of ion channel genes and validate their expression within HGG patient tumors, to identify ion channel-targeting drugs that would inhibit tumor-promoting processes.
Research
Immune impacts of infant whole-cell and acellular pertussis vaccination on co-administered vaccinesWe compared the effect of a heterologous wP/aP/aP primary series (hereafter mixed wP/aP) versus a homologous aP/aP/aP primary schedule (hereafter aP-only) on antibody responses to co-administered vaccine antigens in infants and toddlers.
Research
Efficacy and Safety of Epicutaneous Immunotherapy in Peanut-Allergic Toddlers: Open-Label Extension to EPITOPEThe pivotal phase 3 EPITOPE trial, a 12-month, double-blind, placebo-controlled study of epicutaneous immunotherapy with the VIASKIN patch containing 250 μg of peanut protein (VP250), previously reported significant treatment response versus placebo in peanut-allergic toddlers aged 1 through 3 years.
The Pregnancy and Early Life Immunology team's overall research vision is targeted towards understanding immunological development during early life.
Research
Early biomarkers predictive of autismThis study aims to investigate the cellular and molecular profiles of the immune system in infants at high/low risk for Autism, as determined through clinical assessment.
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Epigenetic changes underpinning allergen sensitization: a twin-based studyWe are studying immune cells from identical twins of which one suffers and one does not suffer from allergic disease to identify specific mechanisms that may play important roles in disease development.
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Finding the cellular explanation for recurrent asthma exacerbationsThis study is designed to identify the specific unique immune cell response that occurs in these children with recurrent disease.
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Targeting the mucosal immune system in a pregnant mouse model to prevent experimental allergic airways disease in the offspringStudies in Europe show exposure of pregnant women to high levels of microbial products stimulate immune function maturation in their offspring
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The cellular effects of estrogen on allergic asthmaThe study aims to identify the mechanism for this so that this knowledge can be used to better treat asthma and allergies in both males and females.
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Mechanisms of IgE sensitizationThis project investigates how cells of the immune system respond to substances to cause allergies to help develop new treatments.