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Research

This project investigates how cells of the immune system respond to substances to cause allergies to help develop new treatments.

News & Events

The Kids Research Institute Australia researchers are investigating whether a simple urine test could predict whether young children with wheezing symptoms will go on to develop asthma.

News & Events

Join us for our Annual Community Lecture entitled "You Are What You Breathe" with Professor Stephen Holgate.

News & Events

Michelle has spent countless nights watching her son struggle to breathe. Our researchers are working to find better treatments for kids living with asthma.

News & Events

The Kids Research Institute Australia researchers are at the forefront of asthma research globally. Watch Karen's story to learn why it's so important.

News & Events

Researchers are urging caution in the use of a widely accepted test for diagnosing asthma, after their study found it may not be accurate in some settings.

News & Events

Asthma researchers at Perth's The Kids for Child Health Research are developing a world first system for predicting the severity of asthma in children

Research

Asthma is among the commonest noncommunicable diseases of childhood and often occurs with other atopic comorbidities. A previous case-control study found evidence that compared to children who received acellular pertussis (aP) vaccines in early infancy, children who received one or more doses of whole-cell pertussis (wP) vaccine had lower risk of developing IgE-mediated food allergy. We hypothesized that wP vaccination in early infancy might protect against atopic asthma in childhood. 

Research

Poor maternal diet during pregnancy is a risk factor for severe lower respiratory infections in the offspring, but the underlying mechanisms remain elusive. Here, we demonstrate that in mice a maternal low-fiber diet led to enhanced LRI severity in infants because of delayed plasmacytoid dendritic cell recruitment and perturbation of regulatory T cell expansion in the lungs.

Research

The airway epithelium of children with wheeze is characterized by defective repair that contributes to disease pathobiology. Dysregulation of developmental processes controlled by Notch has been identified in chronic asthma. However, its role in airway epithelial cells of young children with wheeze, particularly during repair, is yet to be determined.