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Research
Gender and Immunity Study (GIM)The Gender and IMmunity study (GIM) aims to evaluate how gender-affirming hormone therapy impacts the immune system in young trans individuals, and how this translates to short and long-term health outcomes.
Research
Progressive increase of FcεRI expression across several PBMC subsets is associated with atopy and atopic asthma within school-aged childrenThe expression pattern of FcεRI on DC and basophils differentiates asthmatic from non-asthmatic atopic children
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Potential immunological effects of gender-affirming hormone therapy in transgender people – an unexplored area of researchThere are well-described sex-based differences in how the immune system operates. In particular, cisgender (cis) females have a more easily activated immune system; associated with an increased prevalence of autoimmune diseases and adverse events following vaccinations. Conversely, cis males have a higher threshold for immune activation, and are more prone to certain infectious diseases, such as coronavirus disease (COVID-19).
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Epstein–Barr virus infection, B-cell dysfunction and other risk factors converge in gut-associated lymphoid tissue to drive the immunopathogenesis of multiple sclerosis: a hypothesisMultiple sclerosis is associated with Epstein–Barr virus (EBV) infection, B-cell dysfunction, gut dysbiosis, and environmental and genetic risk factors, including female sex.
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Narrowband UVB phototherapy reduces TNF production by B-cell subsets stimulated via TLR7 from individuals with early multiple sclerosisAt the end of a 60-day course of narrowband UVB phototherapy, administered to individuals with early multiple sclerosis, there were changes in the relative proportions of circulating B-cell subsets. This study investigated phototherapy-associated changes to cytokine responses of B cells when exposed to a TLR7 ligand.
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Oestrogen amplifies pre-existing atopy-associated Th2 bias in an experimental asthma modelThe role of oestrogen in experimental atopic asthma, and guide future research on sex-related variations in atopic asthma susceptibility/intensity
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Egg-sensitised infants have elevated CD4+ effector memory T regulatory cells from birthIgE-mediated sensitisation to egg is common in infants. In some cases, the processes leading to egg sensitisation are established in early life, even before introduction to solid foods. The underlying mechanisms remain poorly understood.
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What is triggering immune reactions in people with MS?Multiple sclerosis (MS) is a condition where a person's immune system attacks the brain and spinal cord.
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Circulating Memory B Cells in Early Multiple Sclerosis Exhibit Increased IgA+ Cells, Globally Decreased BAFF-R Expression and an EBV-Related IgM+ Cell SignatureMultiple sclerosis (MS) is an immune-mediated inflammatory disease of the central nervous system that results in demyelination of axons, inefficient signal transmission and reduced muscular mobility. Recent findings suggest that B cells play a significant role in disease development and pathology. To further explore this, B cell profiles in peripheral blood from 28 treatment-naive patients with early MS were assessed using flow cytometry and compared to 17 healthy controls.
Our team aims to better understand how the immune response to immune challenges, such as viral infections can influence the risk of developing asthma or autoimmune disease.
News & Events
New research on youth-onset type 2 diabetes in northern AustraliaExplore new research on youth-onset diabetes at The Kids' Institute, uncovering insights to improve health outcomes for young patients in Northern Australia.
News & Events
Research to help identify which children will develop asthma and to design more specific asthma treatments supported by Federal Government fundingResearch focussed on identifying which children will develop asthma, and developing more specific asthma treatments, has been supported by the National Health and Medical Research Council’s (NHMRC) Ideas Grants announced by the Federal Government on 14 December 2022.
News & Events
Research into innovative treatments for asthma and antibiotic-resistant infections fuelled by Stan Perron Charitable Foundation grantsNew funding from the Stan Perron Charitable Foundation will support research into innovative treatments for antibiotic-resistant infections and asthma in children, led by Wal-yan Respiratory Research Centre researchers.
News & Events
New locally-developed app to support women through pregnancyA new evidence-based app designed to support pregnant women to live a healthy lifestyle and give their baby the best start has been launched by The Kids Research Institute Australia and the Joondalup Health Campus
News & Events
Vitamin D deficiency linked to childhood asthmaResearchers at The Kids Research Institute Australia have found children with vitamin D deficiency are more likely to develop asthma.
News & Events
New study brings hope for preventing lung disease in children with cystic fibrosisResearchers at Perth's Telethon Institute are one step closer to preventing serious lung disease which is the main cause of suffering in cystic fibrosis.
News & Events
New study shows fetal head size could link to autismResearch has found a link between children with larger head measurements in-utero and a subsequent diagnosis of Autism Spectrum Disorder (ASD) as toddlers.
News & Events
Apache Energy joins Telethon Institute in cancer research partnershipApache Energy and the Telethon Institute for Child Health Research today signed a two-year partnership
Research
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes riskLevels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide...
Research
Patterns trends and increasing disparities in mortality for Aboriginal and non-Aboriginal infants born in Western Australia 1980-2001: population database studySince there are known disparities between Aboriginal and non-Aboriginal populations in Australia, trends in infant mortality rates can be used to assess the...