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Single-breath washout and association with structural lung disease in children with cystic fibrosisAcinar ventilation inhomogeneity measured by single-breath washout was not associated with structural lung disease on CT
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Early life exposure to coal mine fire smoke emissions and altered lung function in young childrenInfant exposure to coal mine fire emissions could be associated with long-term impairment of lung reactance
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Mannitol challenge testing for asthma in a community cohort of young adultsWe aimed to quantify the diagnostic utility of mannitol challenge testing for asthma in a community cohort and a symptomatic wheezing subset of this cohort.
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Reference values for spirometry and their use in test interpretation: A Position Statement from the Australian and New Zealand Society of Respiratory ScienceThe ANZSRS recommends the adoption of the Global Lung Function Initiative (GLI) 2012 spirometry reference values throughout Australia and New Zealand
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Multiple breath washout cannot be used for tidal breath parameter analysis in infantsThere are differences in tidal breathing parameters during multiple breath washout testing with SF6 gas mixture in infants
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Impact of lung disease on respiratory impedance in young children with cystic fibrosisThe present study investigated whether lung function measured by forced oscillation technique would be impaired in the presence of infection,...
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Improving screening in a paediatric cohort for cystic fibrosis-related diabetes: A quality improvement projectAndré Schultz MBChB, PhD, FRACP Head, BREATH Team Head, BREATH Team Prof André Schultz is the Head, BREATH Team at The Kids Research Institute
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Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease riskLung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 580,869 participants, we identified 1,020 independent association signals implicating 559 genes supported by ≥2 criteria from a systematic variant-to-gene mapping framework. These genes were enriched in 29 pathways. Individual variants showed heterogeneity across ancestries, age and smoking groups, and collectively as a genetic risk score showed strong association with COPD across ancestry groups.
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Ventilatory response and stability of oxygen saturation during a hypoxic challenge in very preterm infantsPreterm infants have immature control of breathing and impaired pulmonary gas exchange. We hypothesized that infants with bronchopulmonary dysplasia (BPD) have a blunted ventilatory response and peripheral oxygen saturation (SpO2 ) instability during a hypoxic challenge.
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Impact of HIV and antiretroviral drug exposure on lung growth and function over 2 years in an African Birth CohortHIV exposure is associated with altered lung function in early life, with a vulnerable HIV-exposed uninfected subgroup based on maternal disease severity