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Asthma and chronic obstructive pulmonary disease (COPD) are common chronic respiratory diseases, and some patients have overlapping disease features, termed asthma-COPD overlap. Patients characterized with ACO have increased disease severity; however, the mechanisms driving this have not been widely studied.
With immune checkpoint therapy (ICT) having reshaped the treatment of many cancers, the next frontier is to identify and develop novel combination therapies to improve efficacy. Previously, we and others identified beneficial immunological effects of the vitamin A derivative tretinoin on anti-tumour immunity.
Alexander David Deborah Larcombe Martino Strickland BScEnv (Hons) PhD BSc PhD PhD Honorary Research Fellow Head, Chronic Diseases Research Head,
Atopy and asthma are commonly initiated during early life, and there is increasing interest in the development of preventive treatments for at-risk children.
In this study, we aimed to uncover the molecular mechanisms contributing to altered lung structure and function.
Cancer immunotherapy has shown impressive results, but most patients do not respond.
The aim of this study was to examine the gene response of white blood cells in severe allergic reactions to identify genes that could be targets to new drugs...
In utero exposure to arsenic via drinking water increases the risk of lower respiratory tract infections during infancy and mortality from bronchiectasis in...
Our findings provide new insight into the molecular mechanisms operative at baseline in the airway mucosa in atopic asthmatic with natural aeroallergen exposure
This study suggests that broad-spectrum protection-of-pregnancy against infection-associated inflammatory stress represents an achievable therapeutic goal