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Maternal diet modulates the infant microbiome and intestinal Flt3L necessary for dendritic cell development and immunity to respiratory infectionPoor maternal diet during pregnancy is a risk factor for severe lower respiratory infections in the offspring, but the underlying mechanisms remain elusive. Here, we demonstrate that in mice a maternal low-fiber diet led to enhanced LRI severity in infants because of delayed plasmacytoid dendritic cell recruitment and perturbation of regulatory T cell expansion in the lungs.
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Annual Community Lecture: You Are What You BreatheJoin us for our Annual Community Lecture entitled "You Are What You Breathe" with Professor Stephen Holgate.
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Video: The burden of asthma - Michelle's storyMichelle has spent countless nights watching her son struggle to breathe. Our researchers are working to find better treatments for kids living with asthma.
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Video: The burden of asthma - Karen's storyThe Kids Research Institute Australia researchers are at the forefront of asthma research globally. Watch Karen's story to learn why it's so important.
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Researchers urge caution in how asthma test is usedResearchers are urging caution in the use of a widely accepted test for diagnosing asthma, after their study found it may not be accurate in some settings.
Research
Relationship between cytokine expression patterns and clinical outcomes: two population-based birth cohortsOur findings suggest that positive HDM 'allergy tests' and asthma are associated with a broad range of immunophenotypes, which may have important...
Research
Genetic polymorphism of KIR2DL4 (CD158d), a putative NK cell receptor for HLA-G, does not influence susceptibility to asthmaNo reproducible associations with KIR2DL4 genotype were identified, leading us to conclude that the KIR2DL4 9A/10A polymorphism has no influence...
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Association between human rhinovirus C and severity of acute asthma in childrenA new and potentially more pathogenic group of human rhinovirus (HRV), group C (HRVC), has recently been discovered.
Research
Environmental Factors in Children's Asthma and Respiratory EffectsChildhood asthma is a condition characterized by airflow obstruction that varies in time spontaneously, in response to various environmental stimuli...
Research
The advent of recombinant allergens and allergen cloning Authors:When the allergen nomenclature system was adopted in 1986, allergens were identified by their behavior on electrophoresis and chromatography...