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Research

Vitamin D and immunity

The active form of vitamin D has an important role in calcium metabolism and in bone mineralisation, but the evidence for other health outcomes is mixed,...

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Fetal alcohol spectrum disorders: Notifications to the Western Australian Register of Developmental Anomalies

There is increasing attention on fetal alcohol spectrum disorders (FASD) in Australia, but there are limited data on their birth prevalence.

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Altered regulatory T-cell fractions and Helios expression in clinically isolated syndrome: clues to the development of multiple sclerosis

These results indicate that T regulatory (Treg) and follicular T regulatory (Tfr) impairment is an early feature in MS.

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The valuing of upstream approaches across the lifecourse. Fact Sheet 2 for the Aboriginal and Torres Strait Islander Suicide Prevention Evaluation Project

This factsheet highlights the need for a greater understanding of the importance of constructive & preventive ‘upstream’ approaches & sustained investment in...

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Ultraviolet irradiation of mice reduces the competency of bone marrow-derived CD11c+

Direct UV irradiation of dendritic cells and Langerhans cells reduces their Ag presenting ability. However, the effects of UV on CD11c(+) cells located...

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A systematic review: Identifying the prevalence rates of psychiatric disorder in Australia's Indigenous populations

A systematic review: Identifying the prevalence rates of psychiatric disorder in Australia's Indigenous populations.

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Identification of genes differentially regulated by vitamin D deficiency that alter lung pathophysiology and inflammation in allergic airways disease

Vitamin D deficiency exacerbates house dust mite-induced inflammation and alterations in lung structure and function

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Does late childbearing increase the risk for behavioural problems in children? A longitudinal cohort study

This study aimed to examine the relationship between advanced parental age and behavioural outcomes in offspring in a longitudinal cohort of children in...

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Pneumococcal conjugate vaccines PREVenar13 and SynflorIX in sequence or alone in high-risk indigenous infants (PREV-IX-COMBO)

Otitis media (OM) starts within weeks of birth in almost all Indigenous infants living in remote areas of the Northern Territory (NT).

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Vitamin D and allergic airway disease shape the murine lung microbiome in a sex-specific manner

Maintaining sufficient vitamin D is necessary for optimal lung health, and vitamin D may modulate the lung microbiome in a sex-specific fashion

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Prevalence, repairs and complications of hypospadias: An Australian population-based study

To investigate hypospadias' prevalence and trends, rate of surgical repairs and post-repair complications in an Australian population.

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Assessing neutrophil subsets in autoimmune disease: Moving away from relying on density?

Neutrophils are the most abundant immune cell in circulation. However, due to a number of technical challenges for researchers, including the neutrophil's short lifespan and difficulties with preservation, they are often discarded during blood processing and thus ignored in cohort studies. As such, the contribution of neutrophils to disease and their involvement in disease mechanisms is less explored compared with other immune cell types.

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Vitamin D in fetal development: Findings from a birth cohort study

Birth cohort studies provide an invaluable resource for studies of the influence of the fetal environment on health in later life.

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IgG3 + B cells are associated with the development of multiple sclerosis

We have identified previously uncharacterised subsets of IgG3 + B cells and shown them to correlate with autoimmune attacks on the central nervous system

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Detection of biofilm in bronchoalveolar lavage from children with non-cystic fibrosis bronchiectasis

The presence of Pseudomonas aeruginosa biofilms in lower airway specimens from cystic fibrosis (CF) patients is well established.

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Exposure to Ultraviolet Radiation in the Modulation of Human Diseases

This review focuses primarily on the beneficial effects for human health of exposure to ultraviolet radiation

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Pterygium and conjunctival ultraviolet autofluorescence in young Australian adults: The Raine study

Sun exposure is associated with several ophthalmic diseases, including pterygium which may develop in adolescence.