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Research

Maternal HIV infection alters antimicrobial immunity in exposed and uninfected infants

Implementation of lifelong ART of all HIV-infected women has the potential to improve maternal determinants of protective immunity in the young infant

Research

Role of maternal mental health disorders on stillbirth and infant mortality risk: a protocol for a systematic review and meta-analysis

We plan to examine whether prenatal maternal mental health disorders impact the risk of stillbirth and infant mortality

Research

Association between diesel engine exhaust exposure and lung function in Australian gold miners

Diesel engine exhaust exposures were higher in underground miners and had a negative association with their lung function over a single 12-h shift

Research

Factors associated with pneumococcal carriage in children and adults in Fiji, using four cross-sectional surveys

This study describes predictors of pneumococcal nasopharyngeal carriage and density in Fiji. We used data from four annual cross-sectional surveys, pre- and post-introduction of ten-valent pneumococcal conjugate vaccine in October 2012.

Research

The Evolving Landscape of e-Cigarettes: A Systematic Review of Recent Evidence

This review focuses on smokers and nonsmokers and evaluates the most recent data regarding the potential health effects of e-cigarettes

Research

ApoB48-remnant lipoproteins are associated with increased cardiometabolic risk in adolescents

Plasma apoB48 remnant lipoproteins associate with cardiometabolic risk factors in adolescents and provide support for the screening of remnant cholesterol in youth

Research

Assessment of Cannabidiol and Delta9-Tetrahydrocannabiol in Mouse Models of Medulloblastoma and Ependymoma

Children with medulloblastoma and ependymoma are treated with a multidisciplinary approach that incorporates surgery, radiotherapy, and chemotherapy; however, overall survival rates for patients with high-risk disease remain unsatisfactory. Data indicate that plant-derived cannabinoids are effective against adult glioblastoma; however, preclinical evidence supporting their use in pediatric brain cancers is lacking. Here we investigated the potential role for Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in medulloblastoma and ependymoma. Dose-dependent cytotoxicity of medulloblastoma and ependymoma cells was induced by THC and CBD in vitro, and a synergistic reduction in viability was observed when both drugs were combined.