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MYCN sensitizes neuroblastoma to the MDM2-p53 antagonists Nutlin-3 and MI-63We hypothesized that reactivation of p53 by inhibition of its negative regulator will result in p53-mediated growth arrest and apoptosis.
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Virus detection and its association with symptoms during influenza-like illness in a sample of healthy adults enrolled in a randomised controlled vaccine trialViral respiratory infections are associated with significant morbidity and mortality.
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Tertiary paediatric refugee health clinic in Western Australia: Analysis of the first 1026 childrenThe aim of this study is to describe the epidemiology of common conditions in resettled paediatric refugees attending a tertiary multidisciplinary RHC.
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Assessment of cardiometabolic risk in children in population studies: underpinning developmental origins of health and disease mother–offspring cohort studiesPregnancy and birth cohorts have been utilised extensively to investigate the developmental origins of health and disease, particularly in relation to...
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Maternal vitamin D deficiency alters fetal brain development in the BALB/c mouse.Prenatal exposure to vitamin D is thought to be critical for optimal fetal neurodevelopment, yet vitamin D deficiency is apparent in a growing proportion of...
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Chronic cat allergen exposure induces a Th2 cell-dependent IgG4 response related to low sensitizationThis study evaluated the relationship between cat allergen–specific biomarkers in adults with cat allergy with and without cat ownership.
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Cross-presentation of cutaneous melanoma antigen by migratory XCR1+CD103− and XCR1+CD103+ dendritic cellsThis report provides new insight into the functional specialization within the broad network of dendritic cells that are responsible for skin immunosurveillance
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Supply of benzathine penicillin G: the 20-year experience in AustraliaReliable supplies of BPG are essential for delivering the recommended schedule of secondary prophylaxis for people living with RHD.
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Towards a PBMC "virogram assay" for precision medicine: Concordance between ex vivo and in vivo viral infection transcriptomesIn this rhinovirus study, we first hypothesized that ex vivo human cells response to virus can serve as a proxy for otherwise controversial in vivo human...
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Prevalence and patterns of alcohol use in pregnancy in remote Western Australian communities: The Lililwan ProjectAlcohol use in pregnancy is thought to be common in remote Australian communities, but no population-based data are available.