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A novel role for interleukin-1 receptor signaling in the developmental regulation of immune responses to endotoxinSuggests that IL-1R1 expression provides an additional level of Myd88-dependent signaling during this period of heighted susceptibility to infection.
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Neonatal antigen-presenting cells are functionally more quiescent in children born under traditional compared with modern environmental conditionsOne explanation for the high burden of allergic and autoimmune diseases in industrialized countries is inappropriate immune development under modern...
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World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): ProbioticsPrevalence of allergic diseases in infants, whose parents and siblings do not have allergy, is approximately 10% and reaches 20-30% in those with an allergic...
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T-cell activation genes differentially expressed at birth in CD4+ T-cells from children who develop IgE food allergyTo show underlying mechanisms, we examined differences in T-cell gene expression in samples at birth and at 1 year in children with and without IgE allergy.
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World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Vitamin DVitamin D is involved in the regulation of the immune system and it may play a role in the development, severity and course of asthma and other allergic...
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Natural environments, nature relatedness and the ecological theater: connecting satellites and sequencing to shinrin-yokuMechanisms-including aerobiological and epigenetic-that might help explain some of the noted positive health outcomes
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Dysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapyStudy the innate immune function in ulcerative colitis patients who fail to respond to anti-tumor necrosis factor therapy
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Transforming Life: A Broad View of the Developmental Origins of Health and Disease Concept from an Ecological Justice PerspectiveWith emerging research involving green space, the microbiome, biodiversity and positive psychology, we discuss ecological justice in the dysbiosphere
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Analytical bias in the measurement of plasma 25-hydroxyvitamin D concentrations in infantsTo our knowledge, this is the first study to show that the reported 25(OH)D concentration may be influenced by both age and assay type
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High-Rise Apartments and Urban Mental Health—Historical and Contemporary ViewsHigh-rise apartment buildings have long been associated with the poor mental health of their residents