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This study developed and tested a highly usable, and moderately acceptable, smartphone app to improve the psychosocial health of young people living with CF
This study found rhinovirus infection drives necrotic cell death in cystic fibrosis airway epithelial cells
Our data suggest that FRC PC-CTs are less sensitive than TLC PC-CTs and that FB-CTs have similar sensitivity to PC-CTs in detecting lung disease
Our work has identified a clinically relevant host-derived factor that may participate in shaping early events in the aetiology of CF respiratory disease
Pulmonary inflammation in surveillance bronchoalveolar lavage has a cumulative effect on structural lung disease extent, more so than infection
These findings suggest the utility of specific FOT outcomes is dependent on the respiratory disease being assessed
These findings indicate that early CF lung disease is characterized by an increased mucus burden and inflammatory markers without infection or structural lung disease
A better understanding of the innate immune responses by CF airway epithelial cells is needed to identify why viral infections are more severe in CF
Comprehensive scores incorporating clinical, lung function, imaging and laboratory data will become essential in the future for predicting disease progression and for use in clinical trials
This study describes the peer bullying experiences of young people with CF, and examines associations between school bullying and the psychological well-being of these young people