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Research

Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease.

We propose that this system provides a model for the differentiation and adaptation of monocytes entering the intestinal lamina propria.

Research

Bipolar disorder in children and adolescents: diagnostic inpatient rates from 2000 to 2013 in Germany

The rate of Bipolar Disorder as a discharge diagnosis in German minors has increased significantly, consistently exceeding the general trend for a rise in rates for mental disorders

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Molecular actions of Vitamin D in reproductive cell biology

The aim of this work is to review current metabolic and molecular aspects of the VitD-VitD receptor axis in reproductive medicine

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Characteristics associated with clinical severity and inflammatory phenotype of naturally occurring virus-induced exacerbations of asthma in adults

Type 2 inflammation is present in patients during virus-induced asthma exacerbations, to the same degree as non-viral exacerbations

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Distress and psychological morbidity do not reduce over time in carers of patients with high-grade glioma

his study aimed to determine how carer distress and psychological morbidity change over time following a patient's diagnosis of high-grade glioma

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Pre- and probiotics for allergy prevention: time to revisit recommendations?

We discuss how the choice of probiotic strains, timing and duration of administration can critically influence the outcome due to different effects on immune modulation and gut microbiota composition

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Induced sputum to detect lung pathogens in young children with cystic fibrosis

we aimed to determine the sensitivity and specificity of induced sputum with and without airway clearance techniques to detect lower airway pathogens in kids.

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The genetic associations of acute anterior uveitis and their overlap with the genetics of ankylosing spondylitis

These findings also suggest that variants in ERAP1 have a differential impact on the risk of AAU when compared with AS, and hence the genetic risk for AAU...

Research

World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Prebiotics

Develop evidence-based recommendations about the use of prebiotics in the prevention of allergy