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Interleukin-4 modulates type I interferon to augment antitumor immunityDespite advances in immunotherapy, metastatic melanoma remains a considerable therapeutic challenge due to the complexity of the tumor microenvironment. Intratumoral type I interferon (IFN-I) has long been associated with improved clinical outcomes. However, several IFN-I subtypes can also paradoxically promote tumor growth in some contexts.
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Pediatric Endotracheal Tube Cuff Management at Altitude: Implications for Aeromedical Retrieval and Other Austere EnvironmentsChildren are sometimes transported via fixed or rotary wing aircraft for medical care. If they are intubated with a cuffed endotracheal tube (ETT), changes in environmental pressure during transport can alter cuff pressure. Cuff management in this setting varies widely by region and by organization. In this historical review, we sought to delineate the evolution of ETT cuff management in children undergoing aeromedical retrieval in order to progress the field toward an optimum strategy in the future.
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Guiding practice principles for clinicians who work with Indigenous peopleCulturally safe healthcare approaches are important to improve outcomes of Indigenous people. Non-Indigenous clinicians are often ill-prepared to provide such healthcare. The NHMRC Centre for Research Excellence (CRE) especially for First Nations Children has been studying for several years how to improve clinical care for Indigenous children with respiratory disease in hospital, clinic, urban, rural and remote settings.
When author Maurice Sendak first sketched out the story of a rambunctious little boy sent to his room without supper, there’s no way he could have known his rollercoaster tale of childhood imagination would still be speaking to the hearts of wild young things more than six decades on.
More than 80,000 Australian children are expected to benefit from a trial being rolled out to 700 childcare centres across the country that aims to boost declining physical activity levels.
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GAMA projectThis study investigated host gene expression in response to new HIV infection.
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Bronchiectasis Research for Improving Lung Health outcomes and Treatment (BRIGHT)This prospective, longitudinal cohort study will examine airway sputum, lung function, and clinical surveillance data of children with bronchiectasis attending Perth Children’s Hospital.
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Burden of rheumatic heart disease (RHD) and impact of prevention strategies: comprehensive evidence to drive the RHD EndgameThis project will use a multi-jurisdictional linked RHD dataset to establish a baseline burden of RHD in Australia to allow for monitoring the impact of burden over time, and to form the basis of clearly defined targets for the END RHD CRE Endgame Strategy.
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Bush Tucker and Vitamin DThis five-year project in Western Australia (WA) aims to promote vitamin D sufficiency among Aboriginal people by developing food-based dietary strategies to increase vitamin D intakes and by encouraging safe sun exposure.
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Characterising moment-to-moment fluctuation in stress, anxiety and blood glucose levels in adolescents with type 1 diabetesKeely Tim Liz Bebbington Jones Davis MClinPsych/PhD MBBS DCH FRACP MD MBBS FRACP PhD McCusker Postdoctoral Research Fellow in Type 1 Diabetes Co-head