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Effect of Fluoxetine on Obsessive-Compulsive Behaviors in Children and Adolescents With Autism Spectrum Disorders: A Randomized Clinical TrialTreatment with fluoxetine compared with placebo resulted in significantly lower scores for obsessive-compulsive behaviors at 16 weeks
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Reduced heart rate variability in adults with autism spectrum disorderOur data suggest an overall dysregulation in resting autonomic activity in adults with autism spectrum disorder
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The Brain Basis of Comorbidity in Neurodevelopmental DisordersThis review discusses early brain development and the etiological factors that may give rise to atypical developmental trajectories, along with neuroimaging insights
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Characterizing Transdiagnostic Processes Underlying the Drive to Socially Engage: A Multimeasurement Factor Analytic InvestigationAltered drive to socially engage is a transdiagnostic feature across multiple psychopathologies. Yet, lack of clarity regarding specific processes that constitute social drive, along with insufficient measurement methods, has hindered understanding in this area. This study ascertained the feasibility of approximating difficulties within specific fine-grained social drive processes as proposed by 2 theoretical frameworks: “orienting,” “wanting,” “pursuing,” “liking,” “learning,” and “reticence” within a reward processing framework and “orienting,” “seeking and maintaining,” and “liking” within a social motivation framework.
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Dental care experiences and clinical phenotypes in children on the autism spectrumChildren diagnosed with autism spectrum disorder may be at higher likelihood of experiencing poorer oral health and difficulties accessing dental health care. However, identifying which children on the autism spectrum may be more vulnerable to experiencing dental care difficulties is still unknown.
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A systematic review of the biological, social, and environmental determinants of intellectual disability in children and adolescentsThis systematic review aimed to identify the most important social, environmental, biological, and/or genetic risk factors for intellectual disability.
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Characterizing restricted and unusual interests in autistic youthA broad range of interests characterized by unusual content and/or intensity, labeled as circumscribed interests are a core diagnostic feature of autism. Recent evidence suggests that a distinction can be drawn between interests that, although characterized by unusually high intensity and/or inflexibility, are otherwise common in terms of their content (e.g., an interest in movies or animals), labeled as restricted interests and interests that are generally not salient outside of autism (e.g., an interest in traffic lights or categorization), labeled as unusual interests.
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Profiles of circumscribed interests in autistic youthCircumscribed interests encompass a range of different interests and related behaviors that can be characterized by either a high intensity but otherwise usual topic [referred to as restricted interests] or by a focus on topics that are not salient outside of autism [referred to as unusual interests].
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Developmental Vitamin D Deficiency in Pregnant Rats Does Not Induce PreeclampsiaPreeclampsia is a pregnancy disorder characterized by hypertension. Epidemiological studies have associated preeclampsia with an increased risk of neurodevelopmental disorders in offspring, such as autism and schizophrenia. Preeclampsia has also been linked with maternal vitamin D deficiency, another candidate risk factor also associated with autism.
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An evidence-based framework for determining the optimal amount of intervention for autistic childrenThe provision of timely, effective, and socially valid non-pharmacological intervention is at the core of efforts to support the development of young autistic children. These efforts are intended to support children to develop skills, empower their caregivers, and lay the foundation for optimal choice, independence, and quality of life into adulthood.