Prostate cancer is the most commonly diagnosed malignancy and the third leading cause of cancer deaths. GWAS have identified variants associated with…
The number of tRNA isodecoders has increased dramatically in mammals, but the specific molecular and physiological reasons for this expansion remain…
The generous support of West Australians through Channel 7’s Telethon Trust will help support vital child health research at The Kids Research Instit…
The discovery of CRISPR-Cas9 and its widespread use has revolutionised and propelled research in biological sciences.
Canonical RNA processing in mammalian mitochondria is defined by tRNAs acting as recognition sites for nucleases to release flanking transcripts. The…
The mitochondrial genome encodes core subunits of the respiratory chain that drives oxidative phosphorylation and is, therefore, essential for energy…
Sarcomeric gene mutations are associated with the development of hypertrophic cardiomyopathy (HCM). Current drug therapeutics for HCM patients are ef…
The evolutionary acquisition of mitochondria has given rise to the diversity of eukaryotic life. Mitochondria have retained their ancestral α-proteob…
Advances in omics technologies have generated exponentially larger volumes of biological data; however, their analyses and interpretation are limited…
Directed evolution emulates the process of natural selection to produce proteins with improved or altered functions. These approaches have proven to…