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Whereas asthma was rare in the late 1800s and early 1900s, the marked increase in its incidence and prevalence since the 1960s points to substantial gene ×...
An improved understanding of the roles of protein kinases in intracellular signalling and disease progression has driven significant advances in protein...
This review focuses on the scientific rationale for early intervention aimed at asthma prophylaxis and discusses therapeutic approaches
In addition to its role in blocking TH2 effector activation in the late-phase allergic response, IL-10 is a known IgG1 switch factor
Differential network analysis of allergen-induced CD4 T cell responses can unmask covert disease-associated genes and pin point novel therapeutic targets
Rhinovirus (RV) C can cause asymptomatic infection and respiratory illnesses ranging from the common cold to severe wheezing. The aim was to identify how age and other individual-level factors are associated with susceptibility to RV-C illnesses. Longitudinal data from the COAST (Childhood Origins of Asthma) birth cohort study were analyzed to determine relationships between age and RV-C infections. Neutralizing antibodies specific for RV-A and RV-C (three types each) were determined using a novel PCR-based assay.
Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease.
The extent to which maternal smoking in pregnancy (MSP) has persisting effects on respiratory health remains uncertain and the mechanisms involved are not...
Inhaled allergens are known for their immediate and ongoing effects in the respiratory tract (RT).
The house dust mite allergen Der p 2 is one of the most important indoor allergens associated with allergic disease.