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The association between behaviour and genotype in Rett Syndrome using the Australian Rett Syndrome Database

This study compared the behavior profile of cases in the Australian Rett Syndrome Database (ARSD) with those in a British study using the Rett Syndrome...

The First Research Report: patterns and trends in mortality of Western Australian infants, children and young people 1980-2002

The Advisory Council on the Prevention of Deaths of Children and Young People today officially released this report.

Advancing equity: six-year respiratory outcomes in young Indigenous children following early respiratory disease detection

Protracted bacterial bronchitis (PBB), chronic suppurative lung disease (CSLD) and bronchiectasis are parts of a disease spectrum characterised by chronic wet cough (CWC). Untreated PBB can develop into CSLD/bronchiectasis.

Mucosal immune cell priming by intranasally delivered Haemophilus haemolyticus is associated with heterologous protection against influenza and nontypeable Haemophilus influenzae

Intranasal vaccines offer a needle-free strategy to enhance immunity to respiratory infections. We investigated the mechanism of action of a novel intranasal vaccine using the human respiratory commensal Haemophilus haemolyticus, previously shown to protect against nontypeable Haemophilus influenzae otitis media and accelerate clearance of influenza A virus.

Relationship between serum clozapine to N-desmethyclozapine ratio and cognitive performance among people with treatment-resistant schizophrenia

We evaluated the relationship of serum clozapine and N-desmethyl clozapine and their ratio and cognition among people with treatment-resistant schizophrenia, an area that has been sub-optimally researched. 

Exploring the utility of indirect calorimetry to optimise nutrition in paediatric intensive care (ICONIC-1): a prospective observational cohort study protocol

The imprecision of predictive equations has led to recommendations for the use of indirect calorimetry to determine measured energy expenditure in the paediatric intensive care unit. However, the feasibility of newer devices, such as the QNRG+ and the impact of IC-guided nutrition delivery on patient outcomes remains unclear.

Understanding Otitis Media Among Aboriginal Children in the Kimberley Region of Western Australia: An Opportunity to Improve Health Outcomes

To assess the prevalence, clinical features and treatment of otitis media (OM) among Aboriginal children in the Kimberley region of Western Australia, and to determine if a correlation exists between OM and protracted bacterial bronchitis.

Oral Health-Related Quality of Life of Western Australian Refugee Children With Childhood Caries

Dental caries remains the most common chronic childhood condition and in Australia persists as a leading cause of potentially preventable hospitalisation. Despite various public health initiatives and improvements in oral health among the wider community, significant disparities exist among refugee families due to the unique challenges they face.

Quantifying undetected tuberculosis in Ethiopia using a novel geospatial modelling approach

Tuberculosis (TB) is the leading infectious cause of death globally, with approximately three million cases remaining undetected, thereby contributing to community transmission. Understanding the spatial distribution of undetected TB in high-burden settings is critical for designing and implementing geographically targeted interventions for early detection and control.

Quicker team launch times for urgent priority neonatal retrievals: A Quality Improvement Initiative study

Neonatal retrieval networks have adopted time-centric quality metrics as Key Performance Indicators (KPI) for setting and comparing benchmarking standards. Quicker launch time (departure from base), an essential KPI, enables neonatal retrieval teams to rapidly provide higher-level care to sick infants. The Newborn Emergency Transport Services of Western Australia (NETS WA) facilitates neonatal transfers across largest global retrieval area necessitating quicker team launch times for urgent retrievals. NETS WA conducted a quality improvement (QI) study to quicken team launch times for urgent retrievals.