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This study aimed to investigate the effects of different macro-environments on asthma genotype-phenotype associations in 2 geographically separated populations
Anti-viral innate immune responses may be impaired in asthma, although the mechanisms are not well understood.
One of the major challenges in health studies with a spatial dimension is to produce valid and meaningful geographical representations of risk.
The aims of this study were to investigate kinin receptor expression on eosinophils of asthmatic and healthy subjects
In this study, we examined the effects of maternal smoking as a major adverse exposure in early life, on mucosal immune function and allergen sensitization...
There is intense interest in the interaction between microbial compounds and allergy.
The Airway Epithelial Research Team is investigating the role of the epithelium in the development of airway diseases including asthma, cystic fibrosis and lung transplant rejection.
Pat Deborah Holt Strickland PhD, DSc, FRCPath, FRCPI, FAA PhD Emeritus Honorary Researcher Head, Pregnancy and Early Life Immunology Patrick.Holt@
The airway epithelium of children with wheeze is characterized by defective repair that contributes to disease pathobiology. Dysregulation of developmental processes controlled by Notch has been identified in chronic asthma. However, its role in airway epithelial cells of young children with wheeze, particularly during repair, is yet to be determined.
Acute wheezing is one of the most common hospital presentations for young children. Respiratory syncytial virus (RSV) and rhinovirus (RV) species A, B and the more recently described species C are implicated in the majority of these presentations. However, the relative importance and age-specificities of these viruses have not been defined.