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Research

Evaluating the Extent of Clinical Uncertainty Among Treatment Options for Patients with Early-Onset Scoliosis

The objective of this study was to evaluate areas of clinical uncertainty among pediatric spine surgeons regarding the treatment of early-onset scoliosis.

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Diet in the early years of life influences cognitive outcomes at 10 years: A prospective cohort study

The aim of this study was to investigate the association between diet during the first 3 years of life and cognitive outcomes at 10 years of age.

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Immune modulation by UV: Role of vitamin D

In this chapter, evidence for and evidence against the involvement of vitamin D in the immunoregulatory properties of UV radiation is presented.

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Neutrophil Extracellular Traps and Bacterial Biofilms in Middle Ear Effusion of Children with Recurrent Acute Otitis Media

Bacteria persist within biofilms on the middle ear mucosa of children with recurrent and chronic otitis media however the mechanisms by which these...

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Consensus statement for inert gas washout measurement using multiple- and single- breath tests

Inert gas washout tests, performed using the single- or multiple-breath washout technique, were first described over 60 years ago.

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Acute hyperglycaemia does not alter nitric oxide-mediated microvascular function in the skin of adolescents with type 1 diabetes

We assessed the impact of an acute bout of hyperglycaemia on nitric oxide (NO)-mediated microvascular function in the skin of adolescents with type 1...

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UVR-induced immunosupression

Despite considerable advances, the exact mechanism whereby UVR can lead to changes in immune responses is not entirely clear at present, and no...

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The role of nutrition in children's neurocognitive development, from pregnancy through childhood

This review examines the current evidence for a possible connection between nutritional intake (including micronutrients and whole diet) and neurocognitive...

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Reduced immune responses in chimeric mice engrafted with bone marrow cells from mice with airways inflammation.

During respiratory inflammation, it is generally assumed that dendritic cells differentiating from the bone marrow are immunogenic rather than immunoregulatory.

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Transcriptional dynamics reveal critical roles for non-coding RNAs in the immediate-early response

The immediate-early response mediates cell fate in response to a variety of extracellular stimuli and is dysregulated in many cancers.