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Research

PKC activation promotes maturation of cord blood T cells towards a Th1 IFN-γ propensity

A significant number of babies present transiently with low protein kinase C zeta (PKCζ) levels in cord blood T cells, associated with reduced ability to transition from a neonatal Th2 to a mature Th1 cytokine bias, leading to a higher risk of developing allergic sensitisation, compared to neonates whose T cells have 'normal' PKCζ levels. However, the importance of PKCζ signalling in regulating their differentiation from a Th2 to a Th1 cytokine phenotype propensity remains undefined.

Research

The feasibility of a digital health approach to facilitate remote dental screening among preschool children during COVID-19 and social restrictions

Tele-dentistry can be useful to facilitate screening of children, especially those living in rural and remote communities, and during the COVID-19 pandemic. This study evaluated the feasibility of tele-dental screening for the identification of early childhood caries (ECC) in preschoolers using an app operated by their parents with remote review by oral-health therapists.

News & Events

Shopping For Data to Drive Discoveries

What if researchers could shop for different data to help uncover how, when and why chronic conditions such as asthma, obesity, allergies and poor mental health develop?

News & Events

ORIGINS Ch7 News Story

ORIGINS featured on Channel 7 News recently with two family stories of how ORIGINS changed their lives.

News & Events

Tips for protecting your baby in the summer heat

Paediatrician Dr Lana Bell shares her top tips for keeping your baby or toddler cool, well-hydrated and protected as the temperature soars.

News & Events

ORIGINS hits the Daily Mail

Dr Michael Mosley discusses ORIGINS in The Daily Mail

News & Events

Hong Kong researcher highlights importance of nature for children during Joondalup Health Campus visit

Joondalup Health Campus welcomed international researcher Dr Tanja Sobko to share her research on the link between mental health and time spent in nature.

News & Events

Early ORIGINS: Disease prevention starts with the early years

The Joondalup Health Campus and The Kids are investigating how childhood and adult-onset diseases can be prevented during foetal development and in the early years of life.

Sub-Project Initiation and Approval Process

Accessing the ORIGINS cohort, database or biological samples involves a process of review and approval.

For volunteers

ORIGINS is fortunate to have a small passionate and dedicated group of longstanding volunteers.