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There is intense interest in the interaction between microbial compounds and allergy.
Epidemiologic associations between viral lower respiratory infections (LRIs) and asthma in later childhood are well known
The aims of this study were to investigate kinin receptor expression on eosinophils of asthmatic and healthy subjects
Intrauterine growth restriction (IUGR) is associated with asthma. Murine models of IUGR have altered airway responsiveness in the absence of any inflammatory exposure. Given that a primary feature of asthma is airway inflammation, IUGR-affected individuals may develop more substantial respiratory impairment if subsequently exposed to an allergen. This study used a maternal hypoxia-induced mouse model of IUGR to determine the combined effects of IUGR and allergy on airway responsiveness.
There is now considerable evidence demonstrating that both prenatal and postnatal exposure to particular classes of microbial stimuli can provide beneficial signals during early life immune development, resulting in the protection against future inflammatory disease.
In this study, we examined the effects of maternal smoking as a major adverse exposure in early life, on mucosal immune function and allergen sensitization...
Vitamin D deficiency exacerbates house dust mite-induced inflammation and alterations in lung structure and function
Elucidation of early life factors is critical to understand the development of allergic diseases, especially those manifesting in early life such as food allerg
To determine whether changes in 24-hour average background ozone (O₃), nitrogen dioxide (NO₂), carbon monoxide (CO) and particulates < 10 μm (PM₁₀) increase the
No reproducible associations with KIR2DL4 genotype were identified, leading us to conclude that the KIR2DL4 9A/10A polymorphism has no influence...