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House dust allergy and immunotherapy

HDM allergy is associated with asthma, allergic rhinitis and atopic dermatitis.

Vitamin D and atopy and asthma phenotypes in children

The purpose of this Review was to give an overview of the recent research into whether a lack of vitamin D contributes to the development of atopy an…

Suppression of adrenomedullin contributes to vascular leakage and altered epithelial repair during asthma

The anti-inflammatory peptide, adrenomedullin (AM), and its cognate receptor are expressed in lung tissue, but its pathophysiological significance in…

Viral infections and atopy in asthma pathogenesis: New rationales for asthma prevention and treatment

Prospective birth cohort studies tracking asthma initiation and consolidation in community cohorts have identified viral infections occurring against…

Defective aeroallergen surveillance by airway mucosal dendritic cells as a determinant of risk

A hallmark of atopic asthma is development of chronic airways hyper-responsiveness (AHR) that persists in the face of ongoing exposure to perennial...

Febrile respiratory illnesses in infancy and atopy are risk factors for persistent asthma and wheeze

The aim of this study was to explore associations between severe respiratory infections and atopy in early childhood with persisting wheeze and asthm…

Antibacterial antibody responses associated with the development of asthma in house dust mite-sensitised and non-sensitised children

We aimed to measure the antibody development to 2 bacteria in a birth cohort at high risk of allergic disease, and to assess which responses are asth…

Virus infection and allergy in the development of asthma: What is the connection?

Information is accumulating which implicates airway inflammation resulting from respiratory viral infections, acting against a background of atopy.

Telethon Institute research provides new insights into the cause of asthma attacks

Telethon Institute for Child Health Research scientist Dr Anthony Bosco has been recognised for his cutting edge research investigating asthma attacks