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Defective respiratory tract immune surveillance in asthma : A primary causal factor in disease onset and progression

The relative importance of respiratory viral infections vs inhalant allergy in asthma pathogenesis is the subject of ongoing debate.

The safety and feasibility of the inhaled mannitol challenge test in young children

Mannitol challenge tests are used clinically to diagnose asthma and, in particular, exercise-induced broncoconstriction (EIB) in adults and children…

Genetic polymorphism of KIR2DL4 (CD158d), a putative NK cell receptor for HLA-G, does not influence susceptibility to asthma

No reproducible associations with KIR2DL4 genotype were identified, leading us to conclude that the KIR2DL4 9A/10A polymorphism has no influence...

Research reveals new link between Vitamin D, lung bacteria and asthma

A The Kids for Child Health Research study has uncovered a new link between vitamin D levels and asthma.

Vitamin D deficiency and the lung: Disease initiator or disease modifier?

Vitamin D deficiency is a global public health problem and has been associated with an increased incidence and severity of many diseases including di…

Prophylactic use of sublingual allergen immunotherapy in high-risk children: A pilot study

These findings suggest that this modified version of SLIT should be considered for retesting of mucosal-based immunotherapy for atopic asthma prevent…

Reversible Control by Vitamin D of Granulocytes and Bacteria in the Lungs of Mice: An Ovalbumin-Induced Model of Allergic Airway Disease

Vitamin D may be essential for restricting the development and severity of allergic diseases and asthma, but a direct causal link between vitamin D...

Trying to beat asthma caused by exercise

Professor Graham Hall is leading a study looking at exercise-related asthma in young children, and we need volunteers to take part.

Innate affairs of allergens

Activation of receptors of the innate immune system is a critical step in the initiation of immune responses.