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OMIP 076: High-dimensional immunophenotyping of murine T-cell, B-cell, and antibody secreting cell subsetsThere is now considerable evidence demonstrating that both prenatal and postnatal exposure to particular classes of microbial stimuli can provide beneficial signals during early life immune development, resulting in the protection against future inflammatory disease.
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Viral Induced Effects on a Vulnerable Epithelium; Lessons Learned From Paediatric Asthma and Eosinophilic OesophagitisThe epithelium is integral to the protection of many different biological systems and for the maintenance of biochemical homeostasis. Emerging evidence suggests that particular children have epithelial vulnerabilities leading to dysregulated barrier function and integrity, that resultantly contributes to disease pathogenesis.
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Quantifying airway remodelling for research or clinical purposes: How should we normalize for airway size?Citation: Donovan GM, Wang KCW, Elliot JG, James AL, Noble PB. Quantifying airway remodelling for research or clinical purposes: How should we
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Fragranced consumer products: effects on asthmatic AustraliansMost asthmatics would prefer workplaces, healthcare facilities, and environments that are fragrance-free, which could help reduce adverse effects
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Defective function at the epithelial junction: A novel therapeutic frontier in asthma?The airway epithelium forms a highly regulated physical barrier that normally prevents invasion of inhaled pathogens and allergens from the airway lumen.
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Vitamin D and atopy and asthma phenotypes in children: a longitudinal cohort studyVitamin D has been linked in some studies with atopy- and asthma-associated phenotypes in children with established disease,but its role in disease inception...
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Boosting airway T-regulatory cells by gastrointestinal stimulation as a strategy for asthma controlThe hallmark of atopic asthma is transient airways hyperresponsiveness (AHR) preceded by aeroallergen-induced Th-cell activation.
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Th2-associated immunity to bacteria in asthma in teenagers and susceptibility to asthmaBacterial colonisation of the airways is associated with increased risk of childhood asthma
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The importance of environment on respiratory genotype/phenotype relationships in the InuitThis study aimed to investigate the effects of different macro-environments on asthma genotype-phenotype associations in 2 geographically separated populations