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X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes

Systematic sequencing of all X-chromosomal genes in patients with genetic evidence for X-chromosome locus involvement may resolve 58% of Fragile X-negative cases

Environmental microbial exposure and protection against asthma

This article looks at the clinical implications of the research into microbial exposure & protection against asthma.

Poly-arginine and arginine-rich peptides are neuroprotective in stroke models

Using cortical neuronal cultures and glutamic acid excitotoxicity and oxygen-glucose deprivation (OGD) stroke models, we demonstrated that poly-arginine and...

Incidence of nonmelanoma skin cancer in relation to ambient UV radiation in white populations, 1978-2012 empirical relationships

This paper examined dose-response relationships between ambient UVR levels and NMSC incidence at the population level.

Prevention - what is the most promising approach?

This paper is an editorial comment by Professor Patrick Holt on the potential for developing early intervention strategies in children with allergies and asthma

Meeting the needs of young people in hospital

For hospital-based clinicians wishing to establish AYA services, how should they proceed and what might such services look like?

Climate change, child health and the role of the paediatric profession in under-resourced settings

Climate change and its health impacts are increasingly recognised by the world's leading medical organisations and journals.

A novel retro-inverso peptide is a preferential JNK substrate-competitive inhibitor

A novel 18 amino acid peptide PYC98 was demonstrated to inhibit JNK1 activity toward c-Jun.

Maternal Attachment Status, Mother-Child Emotion Talk, Emotion Understanding, and Child Conduct Problems

The present study investigated the relations among maternal attachment status, mother-child emotion talk, child emotion understanding, and conduct problems...

Cholesteryl ester transfer protein gene polymorphisms increase the risk of fatty liver in females independent of adiposity

Environmental factors including excessive caloric intake lead to disordered lipid metabolism and fatty liver disease.