Search
Multiple sclerosis is associated with Epstein–Barr virus (EBV) infection, B-cell dysfunction, gut dysbiosis, and environmental and genetic risk factors, including female sex.
At the end of a 60-day course of narrowband UVB phototherapy, administered to individuals with early multiple sclerosis, there were changes in the relative proportions of circulating B-cell subsets. This study investigated phototherapy-associated changes to cytokine responses of B cells when exposed to a TLR7 ligand.
The expression pattern of FcεRI on DC and basophils differentiates asthmatic from non-asthmatic atopic children
Our findings suggest that the proportion of degranulated basophils can also be associated with recurrent exacerbations
The Gender and IMmunity study (GIM) aims to evaluate how gender-affirming hormone therapy impacts the immune system in young trans individuals, and how this translates to short and long-term health outcomes.
Multiple sclerosis (MS) is a condition where a person's immune system attacks the brain and spinal cord.
There is a greater prevalence of multiple sclerosis (MS), a neurological autoimmune condition, in populations living further from the equator, hypothesised to be due to reduced sunlight exposure. There exists a proven sunlight surrogate therapy for dermatological inflammatory conditions, in the form of narrowband NB-UVB phototherapy. Yet, there is a paucity of randomized trials of the therapeutic delivery of NB-UVB beyond dermatology for conditions with a systemic inflammatory component.
Neutrophils are a type of immune cell that can trigger inflammation and may play a role in the development of MS.
Our team aims to better understand how the immune response to immune challenges, such as viral infections can influence the risk of developing asthma or autoimmune disease.
The overarching aim of this project is to understand how plasmacytoid dendritic cells function in children with asthma and how genes and environmental stimuli influence these cells.