Mitochondria are hubs of metabolic activity with a major role in ATP conversion by oxidative phosphorylation (OXPHOS). The mammalian mitochondrial ge…
Programmable DNA endonucleases derived from bacterial genetic defense systems, exemplified by CRISPR-Cas9, have made it significantly easier to perfo…
The structures and functions of organelles in cells depend on each other but have not been systematically explored. We established stable knockout ce…
Researchers from The Kids Research Institute Australia and The University of Western Australia have developed a new technique to see inside cells wit…
Genomic sequencing in congenital heart disease (CHD) patients often discovers novel genetic variants, which are classified as variants of uncertain s…
Platelets are anucleate blood cells that contain mitochondria and regulate blood clotting in response to injury. Mitochondria contain their own gene…
Breakdown of mitochondrial proteostasis activates quality control pathways including the mitochondrial unfolded protein response (UPRmt) and PINK1/Pa…
The ability to balance conflicting functional demands is critical for ensuring organismal survival. The transcription and repair of the mitochondrial…
The genetic code that specifies the identity of amino acids incorporated into proteins during protein synthesis is almost universally conserved. Mito…
RNA-binding proteins and mitochondrial ribosomes have been found to be linchpins of mitochondrial gene expression in health and disease. The expandin…