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Pregnancy Induces a Steady-State Shift in Alveolar Macrophage M1/M2 Phenotype That Is Associated With a Heightened Severity of Influenza Virus InfectionPregnancy is associated with an alternatively activated phenotype of alveolar macrophage before infection
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Progressive increase of FcεRI expression across several PBMC subsets is associated with atopy and atopic asthma within school-aged childrenThe expression pattern of FcεRI on DC and basophils differentiates asthmatic from non-asthmatic atopic children
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Airway Microbiota Dynamics Uncover a Critical Window for Interplay of Pathogenic Bacteria and Allergy in Childhood Respiratory DiseaseTo complement early allergic sensitization, monitoring NPM composition may enable early detection and intervention in high-risk children
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The intersect of genetics, environment, and microbiota in asthma-perspectives and challengesIn asthma, a significant portion of the interaction between genetics and environment occurs through microbiota. The proposed mechanisms behind this interaction are complex and at times contradictory. This review covers recent developments in our understanding of this interaction: the "microbial hypothesis" and the "farm effect"; the role of endotoxin and genetic variation in pattern recognition systems; the interaction with allergen exposure; the additional involvement of host gut and airway microbiota; the role of viral respiratory infections in interaction with the 17q21 and CDHR3 genetic loci; and the importance of in utero and early-life timing of exposures.
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Protection against neonatal respiratory viral infection via maternal treatment during pregnancy with the benign immune training agent OM-85Incomplete maturation of immune regulatory functions at birth is antecedent to the heightened risk for severe respiratory infections during infancy. Our forerunner animal model studies demonstrated that maternal treatment with the microbial-derived immune training agent OM-85 during pregnancy promotes accelerated postnatal maturation of mechanisms that regulate inflammatory processes in the offspring airways.
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Vitamin D over the first decade and susceptibility to childhood allergy and asthmaWe aimed to research relationships between 25(OH)D levels from birth to 10 y/o and susceptibility to allergic sensitization, respiratory issues and asthma.
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Elucidation of pathways driving asthma pathogenesis: Development of a systems-level analytic strategyWhereas asthma was rare in the late 1800s and early 1900s, the marked increase in its incidence and prevalence since the 1960s points to substantial gene ×...
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Restricted aeroallergen access to airway mucosal dendritic cells in vivo limits allergen-specificChronic innocuous aeroallergen exposure attenuates CD4+ T cell-mediated airways hyperresponsiveness in mice; however, the mechanism(s) remain unclear
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Persistent activation of interlinked type 2 airway epithelial gene networks in sputum-derived cells from aeroallergen-sensitized symptomatic asthmaticsOur findings provide new insight into the molecular mechanisms operative at baseline in the airway mucosa in atopic asthmatic with natural aeroallergen exposure
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Mannitol challenge testing for asthma in a community cohort of young adultsWe aimed to quantify the diagnostic utility of mannitol challenge testing for asthma in a community cohort and a symptomatic wheezing subset of this cohort.