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Acute Lymphoblastic Leukemia (ALL) occurring in the first year of life is rare.

Genotyping has become more cost-effective and less invasive with the use of buccal cell...

Medulloblastoma (MB) is the most common type of malignant childhood brain tumour.

Our study provides evidence that OT-82 is a promising new therapeutic strategy for a broad spectrum of high-risk pediatric acute lymphoblastic leukemia

The largest GWAS meta-analysis conducted to date associating SNPs to venous thromboembolism in children and adolescents treated on childhood ALL protocols

This protocol describes bilateral murine tumor models that display a symmetrical yet dichotomous response to immune checkpoint blockade

Our data shows that the expression of distinct IFNα subtypes within the tumor microenvironment results in different anti-tumor activities

The aim of our study was to investigate whether CBL0137 has potential as a therapeutic and chemopotentiating compound in MLL-r leukemia

In response to DNA damaging chemotherapy, targeting MK2 in p53-mutated cells produces a phenotype that is distinct from the p53-deficient phenotype

In this review we explore the current literature about the predictive characteristics of the tumor microenvironment and discuss therapeutic approaches