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Research
Hypoallergenic der p 1/Der p 2 combination vaccines for immunotherapy of house dust mite allergyMore than 50% of allergic patients have house dust mite (HDM) allergy.
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NHMRC funding awarded to support child health researchThe Kids Research Institute Australia researchers have been awarded more than $10 million in research funding from the National Health and Medical Research Council (NHMRC).
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Switch on the immune system earlyFindings by Professor Pat Holt revealed researchers had been heading down the wrong path in their battle strategy against respiratory allergy and asthma.
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Overseas trip will help unlock the asthma puzzleOne in ten Australians have asthma and Dr Kimberley Wang from The Kids Research Institute Australia is on a mission to find out what causes it.
Research
Comparison of rhinovirus antibody titers in children with asthma exacerbations and species-specific rhinovirus infectionAsthma exacerbations are associated with human rhinovirus (HRV) infections, and more severe exacerbations are associated with HRV-C.
Research
Respiratory allergen from house dust mite is present in human milk and primes for allergic sensitization in a mouse model of asthmaThese data highlight that antigen administration to the neonate through the oral route may contribute to child allergic sensitization and have important...
Research
Vitamin D deficiency causes deficits in lung function and alters lung structureThe prevalence of vitamin D deficiency is increasing and has been linked to obstructive lung diseases including asthma and chronic obstructive pulmonary disease
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Stiffness Mediated-Mechanosensation of Airway Smooth Muscle Cells on Linear Stiffness Gradient HydrogelsIn obstructive airway diseases such as asthma and chronic obstructive pulmonary disease (COPD), the extracellular matrix (ECM) protein amount and composition of the airway smooth muscle (ASM) is often remodelled, likely altering tissue stiffness. The underlying mechanism of how human ASM cell (hASMC) mechanosenses the aberrant microenvironment is not well understood.
Research
LPS binding protein and activation signatures are upregulated during asthma exacerbations in childrenAsthma exacerbations in children are associated with respiratory viral infection and atopy, resulting in systemic immune activation and infiltration of immune cells into the airways. The gene networks driving the immune activation and subsequent migration of immune cells into the airways remains incompletely understood. Cellular and molecular profiling of PBMC was employed on paired samples obtained from atopic asthmatic children during acute virus-associated exacerbations and later during convalescence.
Research
The definition of asthma remission in children: A scoping review by the WAO Paediatric Asthma CommitteeAsthma remission has emerged as a potential therapeutic goal. However, definitions of remission have primarily focused on adult populations, with limited consensus on how remission should be defined in children.