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Birth cohorts in asthma and allergic diseases: Report of a NIAID/NHLBI/MeDALL joint workshopPopulation-based birth cohorts on asthma and allergies increasingly provide new insights into the development and natural history of the diseases.
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Effect of early carriage of streptococcus pneumoniae on the development of pneumococcal protein-specific cellular immune responses in infancyThe aim of this study was to examine the relationship between nasopharyngeal pneumococcal colonization in early life and the development of T cell responses.
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The role of bacterial infections during infancy in asthma developmentIn this project we are studying how interactions between bacteria and viruses in children's airways promote the development of allergy and asthma.
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Modulation of the postnatal maturation of immune function during early life: studies on the effects of natural infections and exposure to the bacterial-derived immunoenhancer OM85Severe winter lower respiratory infections in early life are known to be major risk factors for subsequent development of asthma, and it is also known that the high susceptibility to these infections in infants is due to the functional immaturity of their immune systems.
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Does genetic regulation of IgE begin in utero?Elucidation of early life factors is critical to understand the development of allergic diseases, especially those manifesting in early life such as food allerg
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T regulatory cells in childhood asthmaAsthma is a chronic disease of the airways, most commonly driven by immuno-inflammatory responses to ubiquitous airborne antigens.
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Pneumococcal conjugate vaccination at birth in a high-risk setting: No evidence for neonatal T-cell toleranceConcerns about the risk of inducing immune deviation-associated "neonatal tolerance" as described in mice have restricted the widespread adoption...