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Research
Group A Streptococcus, Acute Rheumatic Fever and Rheumatic Heart Disease: Epidemiology and Clinical ConsiderationsA directed approach to the differential diagnosis of acute rheumatic fever now includes the concept of low-risk versus medium-to-high risk populations
Research
Status of research and development of vaccines for Streptococcus pyogenesVaccines against Streptococcus pyogenes are considered as impeded vaccines because of a number of crucial barriers to development
Research
Changes in the clinical and epidemiological features of group A streptococcal bacteraemia in Australia's Northern TerritoryThis study adds to emerging data suggesting increasing importance of iGAS in low- and middle-income settings globally.
News & Events
Visit from On Track Watch Community Researchers helps build a pathway of looking at two different culturesFor Aboriginal Community Researchers Minitja Marawili and Yunutju Gondarra, the work of the END RHD CRE is deeply personal.
News & Events
Laqueisha's story: living with RHDLaqueisha was just five years old when she was diagnosed with rheumatic heart disease and sent on a 5,000km return trip to Perth for major heart surgery.
Research
Group A streptococcal vaccines: Paving a path for accelerated developmentVaccine prevention of GAS infections and their immunological complications has been a goal of researchers for decades.
Research
Progress toward a global Group A streptococcal vaccineThe desire for an effective vaccine arises from the large burden of disease caused by the bacterium, particularly rheumatic fever and rheumatic heart disease.
Research
A national prospective surveillance study of acute rheumatic fever in Australian childrenAcute rheumatic fever (ARF) is an important cause of heart disease in Indigenous people of northern and central Australia.
Research
Outcomes of latent rheumatic heart disease: External validation of a simplified score in patients with and without secondary prophylaxisSecondary antibiotic prophylaxis reduces progression of latent rheumatic heart disease (RHD) but not all children benefit. Improved risk stratification could refine recommendations following positive screening. We aimed to evaluate the performance of a previously developed echocardiographic risk score to predict mid-term outcomes among children with latent RHD.
Research
Left ventricular remodelling in rheumatic heart disease – trends over time and implications for follow-up in childhoodRheumatic heart disease (RHD) is the most common form of acquired heart disease worldwide. In RHD, volume loading from mitral regurgitation leads to left ventricular (LV) dilatation, increased wall stress, and ultimately LV dysfunction. Improved understanding of LV dynamics may contribute to refined timing of intervention.