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Previous preclinical and clinical trials have shown promising antitumour activity and toxicity profile when employing the ‘Synergy between Immunotherapy and Radiotherapy’ (SITAR) strategy. Approximately, one in seven radiation therapy studies currently recruiting is investigating SITAR.
Glioblastoma in adults, and medulloblastoma and pineoblastoma that mainly affect children, are aggressive brain tumors.
We report on 3 children treated with vismodegib who developed widespread growth plate fusions that persist long after cessation of therapy.
Bevacizumab is well tolerated and appears most effective for rapid tumor control to preserve vision and improve morbidity
This multi-center study provides valuable information on the success rate of establishing patient-derived pre-clinical models of diffuse intrinsic pontine glioma
This chapter summarizes recent advances in diffuse intrinsic pontine glioma and potential novel therapies
We identified previously unidentified gene fusions involving the MET oncogene in pediatric glioblastoma
The trivalent inactivated influenza vaccine is safe, immunogenic, provides clinical protection and should be administered annually to immunosuppressed children receiving treatment for cancer
This study investigates the different patterns of relapse in patients with central nervous system mixed malignant germ cell tumors - treated with chemotherapy.
This study investigated the relapse and outcome patterns of patients with central nervous system mixed malignant germ cell tumors treated with chemotherapy-only