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Although debate surrounding the mechanism or mechanisms governing this causal pathway remains intense, demonstration of the capacity of pretreatment...

Research

Eczema often precedes the development of asthma in a disease course called the 'atopic march'.

Research

The epidemic increase in the prevalence of allergic disease, which first started in the industrialized countries in the 1960s, may have reached a peak in the...

Research

An improved understanding of the roles of protein kinases in intracellular signalling and disease progression has driven significant advances in protein...

Research

Atopic asthma, which is at its highest prevalence during childhood/young adulthood, represents the main focus of this review.

Research

The developing immune system and allergy

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The authors previously reported an increased risk of hospitalisation for acute lower respiratory infection up to age 2 years in children delivered by...

Research

To determine the potential longer-term effects of maternal antenatal respiratory syncytial virus (RSV) vaccination, we examined the association between cord-blood RSV-neutralizing antibodies (RSV-NA) and RSV infections in the first 2 years of life, RSV-NA at 3 years, and respiratory health to age 5 years.

Research

Here we review the historical origins of exposome research and define a new concept, the metaexposome

Research

In addition to its role in blocking TH2 effector activation in the late-phase allergic response, IL-10 is a known IgG1 switch factor