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These results indicate that anaphylaxis is not a major cause of adverse reactions to benzathine penicillin G

This report provides an update on the contemporary global and regional policy landscapes relevant to rheumatic heart disease

increased adherence to penicillin prophylaxis is associated with reduced acute rheumatic fever recurrence and a likely reduction in mortality

Population-based primary prevention of ARF through sore throat management may be effective in well-resourced settings like New Zealand

Health systems did not meet the needs of pregnant Aboriginal women with rheumatic heart disease

A multifaceted intervention was implemented using quality improvement and chronic care model approaches to improve delivery of penicillin prophylaxis for rheumatic heart disease

This strategy did not improve adherence to rheumatic heart disease secondary prophylaxis within the study time frame.

The rates of RHD in Timor-Leste are among the highest in the world, and prevalence is higher among girls than boys. Community engagement is essential for ensuring follow-up and the effective delivery of secondary prophylaxis.

Jonathan Carapetis AM AM MBBS FRACP FAFPHM PhD FAHMS Executive Director; Co-Head, Strep A Translation; Co-Founder of REACH 08 6319 1000 contact@

The spectrum of diseases caused by Streptococcus pyogenes (Strep A) ranges from superficial to serious life-threatening invasive infections. We conducted a scoping review of published articles between 1980 and 2021 to synthesize evidence of state transitions across the Strep A disease spectrum. We identified 175 articles reporting 262 distinct observations of Strep A disease state transitions.